John J. Miller, MD, discusses an increasingly important and clinically relevant issue in psychiatry. According to Dr Miller, "We are at the point in time where we have a much greater sophistication and understanding of what is happening when a drug enters into the brain circuit and interfaces with receptors."

Dr Miller is Medical Director, Brain Health, Exeter, NH; Editor in Chief, Psychiatric Times; Staff Psychiatrist, Seacoast Mental Health Center, Exeter, NH; Consulting Psychiatrist, Exeter Hospital, Exeter, NH; Consulting Psychiatrist, Insight Meditation Society, Barre, MA.