“Off Label” Does Not Mean “Off Limits”
October 22, 2019
Practicing clinical medicine is challenging and stressful enough without the additional burden of being handcuffed by ever-changing medication formularies.
John J. Miller, MD
A Drug’s Journey: From the Pill Bottle to the Toilet
September 23, 2019
Most drugs, after journeying through the various metabolic systems throughout the body, find their exit.
Optimizing Brain Health
July 11, 2019
Each moment of each day we make choices that can affect our brain health—our challenge is, without judgment, to increase the choices that promote a healthy brain.
Psychiatric Pharmacogenomic Testing: The Evidence Base
June 19, 2019
An impressive and ever-expanding research literature exists on the topic of pharmacogenomics. Despite this, only four genes have been vetted as clinically actionable.
Depression’s Journey From Monoamines to Glutamate
May 21, 2019
Psychiatry has finally crossed into a new paradigm in the treatment of TRD, bringing the glutamate system on board to join the modulation of the monoamine systems.
Is It Time to Legalize Cannabis?
April 16, 2019
The controversial question of whether to legalize cannabis has emerged front and center as an important issue that deserves a serious and thoughtful dialogue.
Looking at the Past and Forward to the Future
March 25, 2019
We have come a long way in psychiatry, but we are still at the beginning of the story of understanding the human brain.
Cariprazine May Decrease Substance Abuse in Patients With Bipolar I Disorder
March 15, 2019
Substance use disorders are a common comorbidity in individuals with bipolar disorder. Adding cariprazine to their medication regimen may improve symptoms of both disorders.
Major Depressive Episode: Is It Bipolar I or Unipolar Depression?
July 31, 2018
Since the choice of treatments for a primary bipolar I disorder major depressive episode versus a unipolar major depressive episode are significantly different, this information will help guide clinicians in how to proceed.
Antidepressants, Part 2: Kinetics, Dynamics, Mechanisms of Action, and the Future
November 20, 2017
The author explores the significant pharmacokinetic and pharmacodynamic heterogeneity of current antidepressants and reviews the many potential drug targets that exist—with a focus on the serotonin system.
