Hiroto Ito, PhD


Effect of Gender Differences on the Cardiovascular System in Patients With Mental Disorders

January 01, 2005

Tricyclic antidepressants and antipsychotics are known to prolong cardiac repolarization and induce QTC interval prolongation, possibly putting patients with mental disorders at higher risk of cardiovascular diseases. The mechanism of gender difference in vulnerability for cardiovascular diseases is still unclear, but the role of hormones is one of possible explanatory factors.