Richard C. Shelton, MD


The Neurobiology of Treatment-Resistant Depression

September 01, 2007

Treatment-resistant unipolar major depression appears to be the rule rather than the exception. This view is supported by data from the STAR*D program, a multilevel treatment trial for major depression.

Novel Antipsychotics for Treatment-Resistant Depression

October 01, 2004

Given that a substantial minority of patients don't respond to monotherapy, clinicians may have to consider combined or augmentation therapy. According to the research, which drugs are most effective, and in which combinations?