
- Vol 38, Issue 3
- Volume 03
Adult-Onset ADHD Raises Questions
Before starting to prescribe stimulants to every adult who cannot concentrate, it is important to take a closer look at the research.
NEUROPSYCHIATRY
Four recent studies may have turned what we know about attention-deficit/hyperactivity disorder (ADHD) on its head. By following large cohorts from early childhood to adulthood, they claim to have discovered that ADHD can start in adults who did not have the disorder before the DSM-5 cutoff of 12 years. However, before we rewrite the DSM and start prescribing stimulants to every adult who cannot concentrate, it is important to take a closer look at this
In 3 of the 4 papers, the adult-onset ADHD actually
The fourth paper claimed to identify new-onset ADHD in middle-aged adults, and it made the biggest headlines.4 The study followed a group of more than 1000 residents of New Zealand from aged 3 to 38 years as part of a larger investigation on the effects of adverse birth experiences on health. Researchers gathered symptoms of ADHD at 3 time points: ages 5 to 7; 11 to 15; and finally at age 38. What they discovered surprised them. Most of the children with ADHD no longer had the full disorder as adults, and most of the adults who met criteria for ADHD in middle age did not have the full disorder in childhood. The problem with this surprise discovery is that they did not ask the participants when their ADHD symptoms began, so these may have been teenaged-onset cases like we saw in the other 3 studies.
Comorbid Confounders and Other Confusions
The New Zealand study counted 27 adults with ADHD who did not have the full disorder in their childhood. A quick breakdown of those cases suggests that other disorders could have caused the attention problems endorsed by these patients.4 Specifically, 10 patients had conduct disorder in childhood; 15 had substance use disorders as adults; and 15 sought treatment for major psychiatric disorders as adults.
Two other studies that looked at purported cases of adult-onset ADHD
If adult-onset ADHD does exist, it may not be the same disorder as childhood-onset ADHD. Indeed, most cases of adult-onset ADHD can be better explained as true ADHD that was partially expressed in childhood; false positives in patients whose symptoms are due to another disorder; or false positives in healthy people who overendorsed their symptoms during the
But what if there remains a small number of individuals whose ADHD genuinely begins in adulthood? These studies point to that possibility, but they do not tell us whether these cases share common biological markers, familial patterns, and treatment response with childhood-onset ADHD. The gender distribution, for example, was different, with more males in the childhood-onset cases.
False Positives and Negatives
When someone goes through the effort to see a psychiatrist, there is a good chance that they have a real psychiatric problem. Or, as Groucho Marx put it, “Anyone who goes to a psychiatrist ought to have their head examined.” With community samples, the working assumption is that the participants are “normal,” which is why this kind of research is so prone to false positives. The
Although these studies attempted to rule out other causes of adult-onset ADHD, those exclusions are hampered by false-negative rates. For example, it is not unusual for patients to forget past episodes of mania or psychosis, and those episodes often cause long-standing cognitive problems that could be mistaken for ADHD. Some important causes, like autism spectrum or personality disorders, were not evaluated in these studies.
The Bottom Line
If nothing else, these studies are a good reminder to look for a cause before you reach for a stimulant. In practice, the first thing to do when a patient presents with adult-onset ADHD is to screen for other psychiatric disorders that might explain the symptoms. Medical and environmental factors, including age-related cognitive decline, sleep deprivation, sleep apnea, inflammation, obesity, air pollution, chemical exposure, and excessive use of digital media, can also
Dr Aiken is the Mood Disorders Section Editor for Psychiatric TimesTM, the editor in chief of The Carlat Psychiatry Report, and the director of the Mood Treatment Center. He has written several books on mood disorders, most recently The Depression and Bipolar Workbook. The author does not accept honoraria from pharmaceutical companies but receives royalties from PESI for The Depression and Bipolar Workbook and from W.W. Norton & Co. for Bipolar, Not So Much.
Read the slideshow:
References
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3. Caye A, Rocha TB, Anselmi L, et al. Attention-deficit/hyperactivity disorder trajectories from childhood to young adulthood: Evidence from a birth cohort supporting a late-onset syndrome. JAMA Psychiatry. 2016;73(7):705-712.
4. Moffitt TE, Houts R, Asherson P, et al. Is adult ADHD a childhood-onset neurodevelopmental disorder? Evidence from a four-decade longitudinal cohort study. Am J Psychiatry. 2015;172(10):967-977.
5. Sibley MH, Rohde LA, Swanson JM, et al.
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8. Ra CK, Cho J, Stone MD, et al. Association of digital media use with subsequent symptoms of attention-deficit/hyperactivity disorder among adolescents. JAMA. 2018;320(3):255-263.
9. Park J, Sohn JH, Cho SJ, et al. Association between short-term air pollution exposure and attention-deficit/hyperactivity disorder-related hospital admissions among adolescents: A nationwide time-series study. Environ Pollut. 2020;266(Pt 1):115369.
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11. Dunn GA, Nigg JT, Sullivan EL. Neuroinflammation as a risk factor for attention deficit hyperactivity disorder. Pharmacol Biochem Behav. 2019;182:22-34.
12. Cook RL, O’Dwyer NJ, Donges CE, et al. Relationship between obesity and cognitive function in young women: the food, mood and mind study. J Obes. 2017;2017:5923862.
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