
International Study of Schizophrenia and Violence
A new meta-analysis identifies target for improved care in patients with schizophrenia.
Daniel Whiting, BM, BCh, Department of Psychiatry,
The investigators identified 24 studies of violence perpetration outcomes in 15 countries involving 51,309 individuals with
Whiting et al found an increase in the risk of violence perpetration in men with schizophrenia and other psychoses (pooled OR, 4.5; 95% CI, 3.6-5.6) with substantial heterogeneity (I2 = 66%; 95% CI, 31-83) as well as an elevated risk of violence perpetration in women (pooled OR, 10.2; 95% CI, 7.1-14.6), with substantial heterogeneity (I2 = 66%; 95% CI, 31-83). They further found the absolute risks of violence perpetration in register-based studies were less than 1 in 20 for women with schizophrenia spectrum disorder, compared to less than 1 in 4 in men over a 35-year period.
“Violence perpetration outcomes in individuals with schizophrenia spectrum disorders contribute to morbidity and mortality at a population level, disrupt care, and lead to stigma,” Whiting and colleagues wrote. “Violence perpetration outcomes may be an important target for prevention and to reduce stigma in people with schizophrenia spectrum disorders.”
Reference
1. Whiting D, Gulati G, Geddes JR, Fazel S.
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