Mood and anxiety disorders are the most frequently reported psychiatric comorbidities with epilepsy, with a prevalence of 20% to 22%; however, in select populations, the prevalence can reach 50%.

Reasons for the association are both biological and psychosocial.

 that brings about a number of social limitations and discriminations that lead to demoralization and poor self-esteem. Moreover, epilepsy and mood disorders seem to share a common neurobiology, with involvement of the limbic structures and the modulation of major neurotransmitter pathways by anticonvulsant medications.

Epilepsy and Seizures: Neuropsychiatric Implications

,” by Marco Mula, MD, on which this quiz was based.


1. Tellez-Zenteno JF, Patten SB, Jetté N, et al. Psychiatric comorbidity in epilepsy: a population-based analysis. 

This quiz was originally posted on October 16, 2014, and has since been updated. -Ed

Major Depressive Disorder

Anxiety & Stress Disorders

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What medical condition is most frequently reported with comorbid mood and anxiety disorders? Take the quiz and learn more.