First AD

Second AD

Cannabis contains many different compounds. Based on the current evidence, how does cannabis affect psychosis?

C. THC may exacerbate psychotic symptoms. CBD may have therapeutic effects on psychosis 

E. Cannabis has no therapeutic effect on psychosis

When discussing the medicinal use of cannabis, it is important to distinguish CBD, with its potential beneficial effects, from THC, with its controversial adverse effects, especially on individuals with psychotic disorders.

With more than 100 types of cannabinoids, cannabis is a complex plant. Its main psychoactive compound is Î-9- tetrahydrocannabinol (THC), which activates cannabinoid receptors to produce its psychoactive effects of “feeling high.”

Another cannabinoid, cannabidiol (CBD) does not bind to cannabinoid receptors and has shown different, sometimes counteractive, effects.

The potential beneficial effects of CBD on cognition in patients with schizophrenia have critical importance, since cognitive deficits are common in schizophrenia (up to 75%-85% of patients), usually precede other symptoms, and respond minimally to the available pharmacological treatments.

Cannabidiol as an Adjunctive Treatment for Schizophrenia

Mini Quiz: Medicinal Use of Cannabis for Psychosis?

Anahita Bassir Nia, MD