
Mood Bias: A Partial Explanation of Bipolar Disorder?
A working model that explains how a single shift can produce seemingly opposite symptoms.
Luis, cold from cleaning up the garden in winter, turns the thermostat to 72 trying to warm himself. Joanna then comes in hot from her daily run, and turns it down to 68 again. Luis feels even colder, checks the thermostat, and in irritation, turns it up to 74 (in part to protest!).
Luis’s and Joanna’s body temperatures have biased their perception and their behavior. The usual “negative feedback system” of the thermostat has temporarily become a positive feedback loop: their experience and their behavior are driving their house temperature to extremes. Recent data suggest a similar mechanism might help explain manic and depressive mood shifts.
People with bipolar disorder and their first-degree relatives are more sensitive to life’s
A model for cycling
As has long been recognized, mood itself can alter the experience of reward: when mood is good, a small positive event can be experienced as a greater positive than when mood is bad-eg, discovering that your roommate has turned up the thermostat in advance of your return from a frigid outdoors. On a bad day, you might even think “we agreed not to do that!” instead of focusing on her gracious anticipation of your needs.
As you also know, life is dealing out good as well as bad cards all the time. Granted, some people get far more bad cards than others: they are not being dealt to from the same deck as we far more privileged few. Nevertheless, even for the less fortunate, life still offers a variety of experiences, good and bad events.
Now see the
Eventually, the furnace will kick in and Luis will feel warmer. Eventually the room will get too warm, even for him, and he will turn the thermostat down. Similarly, after you misinterpret your mother, eventually your mood bias could become so extreme that your expectations of reward become overly low. At that point even a neutral event might be experienced as a positive-the purple line in the middle of the
If this goes on too long, however, your bias in perception could become overly positive: eg, now you think your mother is fully approving of the dinner you just presented, missing the slight frown. If this positive bias persists, it could create a positive feedback loop in the opposite direction, pushing your mood toward hypomania and mania (eg, thinking everyone loved the dinner, and you should throw another party soon, a bigger one).
As in the depression loop, the model predicts that eventually your overly positive bias in perception shown on the right side of the
Just a theory?
If this model is valid, the magnitude of individuals’ mood swings should correlate with the magnitude of their reward bias. Sure enough it does. In a study of mood and reward sensitivity published in Nature Communications (
Based on this and other research, these authors recently
References:
1. Meyer B, Johnson SL, Winters R.
2. Johnson SL, Edge MD, Holmes MK, Carver CS.
3. Eldar E, Niv Y.
4. Mason L, Eldar E, Rutledge RB.
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