Author | Amanda C. Peltier, MD, MS


The Clinical Management of Amyotrophic Lateral Sclerosis

March 01, 2007

Amyotrophic lateral sclerosis (ALS) is a progressive, debilitating, fatal disease that involves degeneration of upper and lower motor neurons. Patients often initially present with limb or bulbar weakness, atrophy, and spasticity, followed by progressive loss of ambulation and, ultimately, respiratory failure, which is the most common cause of death.