13 Psychiatric Drugs With Novel Mechanisms: A Timeline
Some speculate the pharmaceutical industry has virtually abandoned new drug development in neuroscience with a few exceptions. However, it should be noted that progress has been made.
Some speculate the pharmaceutical industry has virtually abandoned new drug development in neuroscience with a few exceptions. However, it should be noted that progress has been made.
1987 FDA approval of our first selective serotonin reuptake inhibitor: fluoxetine.
1989: FDA approval of our first and paradigm changing atypical antipsychotic for refractory schizophrenia. Clozapine.
1989 FDA approval of our first drug to treat obsessive-compulsive disorder, which was synthesized by chlorinating imipramine and resulting in a higher potency of elevating brain serotonin: clomipramine.
1994 FDA approval of our first alpha-2-delta subunit antagonist of the neuronal voltage-gated calcium channel: gabapentin (followed by its sibling pregabalin).
1998: FDA approval of our first phosphodiesterase type 5 inhibitor for the treatment of erectile dysfunction.
2002 FDA approval of our first dopamine-2 receptor antagonist/partial agonist: aripiprazole.
2006 FDA approval of our first cholinergic nicotinic subreceptor specific drug for the treatment of cigarette smoke cessation, which has high-affinity partial agonism for the α4β2 nicotinic acetylcholine receptor subtype: varenicline.
2014 FDA approval of our very first selective, dual orexin receptor antagonist (DORA) for the treatment of insomnia: suvorexant.
2015 FDA approval of our very first dopamine-3 selective/dopamine-2 antagonist partial agonist: cariprazine.
2016 FDA approval of our first serotonin 5HT-2A inverse agonist/antagonist for the treatment of hallucinations and delusions associated with Parkinson disease: pimavanserin.
2017 FDA approval of our very first drugs for the treatment of tardive dyskinesia by the novel mechanism of inhibiting the vesicular monoamine transporter, type 2 (VMAT-2): deutetrabenazine and valbenazine.
2019 FDA approval of our very first glutamate specific drug for treatment-resistant depression: esketamine.
For more on this topic, see My Wow and Awesome Responses While Reading the Psychiatric Literature, on which this slideshow is based.