Impaired Glucose Homeostasis in First-Episode Schizophrenia

March 2, 2017

Recent findings suggest metabolic abnormalities may be independent of the effects of antipsychotics.

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References:

1. Mitchell AJ, Vancampfort D, Sweers K, et al. Prevalence of metabolic syndrome and metabolic abnormalities in schizophrenia and related disorders-a systematic review and meta-analysis. Schizophr Bull. 2013;39:306-318.

2. Mitchell AJ, Vancampfort D, De Herdt A, et al. Is the prevalence of metabolic syndrome and metabolic abnormalities increased in early schizophrenia? A comparative meta-analysis of first episode, untreated and treated patients. Schizophr Bull. 2013;39:295-305.

3. Upthegrove R, Manzanares-Teson N, Barnes NM. Cytokine function in medication-naive first episode psychosis: a systematic review and meta-analysis. Schizophr Res. 2014;155:101-108.

4. Fernandes BS, Steiner J, Bernstein HG, et al. C-reactive protein is increased in schizophrenia but is not altered by antipsychotics: meta-analysis and implications. Mol Psychiatry. 2016;21:554-564.

5. Flatow J, Buckley P, Miller B. Meta-analysis of oxidative stress in schizophreniaBiol Psychiatry. 2013;74:400-409.

6. Pillinger T, Beck K, Gobjila C, et al. Impaired glucose homeostasis in first-episode schizophrenia: a systematic review and meta-analysis. JAMA Psychiatry. 2017 Jan 11. doi: 10.1001/jamapsychiatry.2016.3803.