
- Vol 38, Issue 8
Medication Decisions for Women of Childbearing Potential
Bipolar disorder and pregnancy: what considerations need to be kept in mind?
BIPOLAR UPDATE
Medication decisions during pregnancy are always a challenge, and, since many pregnancies are unplanned, considerations should start well before pregnancy occurs and should be addressed again if the patient becomes pregnant. Patients with bipolar disorder who stop medication during pregnancy can have a relapse rate of 80% for depression, 16% for mania, and 4% for mixed episodes
Ranking Treatment Options
Lithium has fewer malformation risks than valproate and carbamazepine. In a
Note that these observational studies involved comparisons of women with bipolar disorder taking lithium vs those not taking lithium. Rates of cardiac abnormalities are lower in women without bipolar disorder. The study results were often unclear if they excluded women who were on other teratogenic medications or were misusing any substances like alcohol. The authors12 concluded that the risks of lithium exposure during pregnancy are low. The risks associated with mood episode relapse following lithium cessation or lowering the level below the therapeutic range appear, for most women, to exceed the harms of fetal abnormalities or other pregnancy complications associated with continuing lithium.
Thus, lithium is preferred over valproate and carbamazepine. For some patients, lithium should be the first choice. For bipolar depression, the second-generation antipsychotics (eg, lurasidone, quetiapine, cariprazine) are reasonable choices, although the data on safety in pregnancy for the newer drugs are limited. Depot antipsychotics should not be routinely used in pregnancy; infants may show extrapyramidal symptoms for months. Anticholinergic drugs should not be prescribed to pregnant women except for acute, short-term need.
Recommendations
Avoid valproate in any woman with the potential to become pregnant. Should the patient become pregnant, it may be too late to discontinue it before harm is done. High-dose folate (4-5 mg daily) has been recommended if valproate or carbamazepine are essential, but the protective effect occurs only if used prior to conception.16
Lamotrigine may be considered for bipolar depression.
Prescribe as few drugs as possible—ideally only 1 medication. When pregnancy unexpectedly occurs during treatment, it is usually best to continue the regimen to avoid exposure to additional agents—except if the patient is on valproate or carbamazepine. In such cases, switching to something safer should be considered. Adjust doses as pregnancy progresses. Blood volume expands 30% in the third trimester. Plasma level monitoring is helpful.
Dr Osser is associate professor of psychiatry at Harvard Medical School and co-lead psychiatrist at the US Department of Veterans Affairs, National Telemental Health Center, Bipolar Disorders Telehealth Program, Brockton, Massachusetts. The author reports no conflicts of interest concerning the subject matter of this article.
References
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8. Jentink J, Dolk H, Loane MA, et al; EUROCAT Antiepileptic Study Working Group.
9. Dolk H, Wang H, Loane M, et al.
10. Vajda FJE, Dodd S, Horgan D.
11. Patorno E, Huybrechts KF, Bateman BT, et al.
12. Fornaro M, Maritan E, Ferranti R, et al.
13. Huybrechts KF, Hernández-Díaz S, Patorno E, et al.
14. Park Y, Hernández-Díaz S, Bateman BT, et al.
15. Leiknes KA, Cooke MJ, Jarosch-von Schwender L, Harboe I, Høie B.
16. Taylor DM, Barnes TRE, Young AH. The Maudsley Prescribing Guidelines in Psychiatry. 13th ed. Wiley Blackwell; 2018:610. ❒
Articles in this issue
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The Epitome of Humanityabout 4 years ago
Strategies for Successful Medical Practicesabout 4 years ago
Diagnosing and Treating Psychotic Disorders in Late Lifeabout 4 years ago
Why Married Men Live Longerabout 4 years ago
COVID-19 Brings Anosmia to the Attention of Psychiatristsabout 4 years ago
Fibromyalgia: What It Is and How to Treat Itabout 4 years ago
I Had to Useabout 4 years ago
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