SPOTLIGHT -
The Economic Burden of Schizophrenia
$chizophrenia: Researchers estimated the economic burden of schizophrenia in the United States.
Vitamin D Augmentation in Major Depression With Comorbid Vitamin D Deficiency
D for Depression? Researchers performed a 12-week, randomized, double-blind placebo-controlled trial of vitamin D augmentation for major depression with vitamin D deficiency.
Renal Function After Lithium Withdrawal
Lithium and the kidneys: Researchers analyzed the effects of withdrawal of chronic lithium therapy on renal function.
Omega-3 Fatty Acids for Depression With Inflammation
“Fishing” for novel approaches to depression: Researchers performed randomized dose-finding trial of omega-3 fatty acids for depression with inflammation.
Calcium-Channel Blocker and Adenosine Modulator Use and Risk of Hospitalization in Bipolar Disorder
Researchers performed a nationwide cohort study of the use of calcium-channel blockers and adenosine modulators and risk of hospitalization in bipolar disorder.
Effects of LSD and Psilocybin in Healthy Participants
In a well-blinded study, researchers investigated and directly compared the acute effects of LSD and psilocybin in healthy participants.
Dextromethorphan-Bupropion in Depression
A new—cough, cough—combination treatment for depression. Researchers performed an RCT of dextromethorphan-bupropion in major depressive disorder.
First Trimester Antipsychotic Exposure and Pregnancy Outcomes
Will it hurt my baby? Researchers investigated associations between first trimester exposure to second-generation antipsychotics and major congenital malformations.
Dosing Adjunctive Aripiprazole for Treatment-Refractory Depression
What is the optimal dose of aripiprazole as augmentation for treatment-refractory depression? Researchers performed a systematic review and dose-effect meta-analysis.
Bipolar Disorder in Perinatal Women
Researchers performed a systematic review and meta-analysis of the prevalence of bipolar disorder and associated mood episodes in perinatal women.
Comorbidity Complexities: Patterns and Implications
A recent study demonstrates how large-scale, real-world data analyses can elucidate patterns of disease comorbidity.
Effects of Nutrition on Mood Variability in Bipolar Disorder
This diet was associated with significant reductions in variability of symptoms in patients with bipolar disorder.
A Randomized Controlled Trial of N-Acetylcysteine in Clozapine-Resistant Schizophrenia
Getting the “NAC” of treating negative symptoms: Researchers performed a randomized controlled trial of N-acetylcysteine in clozapine-resistant schizophrenia.
Longitudinal Study of Sleep and ADHD Symptoms
Good night, sleep tight! Researchers performed a 9-year follow-up of sleep disturbance and ADHD symptoms in a population-based cohort study.
Metabolic Syndrome, Obesity, and Suicide in Bipolar Disorder
Cardiometabolic risk factors for suicide? Researchers investigated associations between obesity/metabolic syndrome and suicidality in patients with bipolar disorder.
Antipsychotic Selection Is Important for Reduced Nonadherence in Schizophrenia
Researchers performed a nationwide register-based study of primary antipsychotic nonadherence in schizophrenia.
Outcomes With Early Long-Acting Injectable Antipsychotic Use in Schizophrenia
Does the “early bird get the worm”? Researchers investigated long-term outcomes with an early-switch long-acting injectable antipsychotic in patients with schizophrenia using a population-based cohort.
Thyroid Function in Drug-Naïve Bipolar Disorder
Do your patients have abnormal thyroid indices? Researchers performed a comparison of thyroid function based on mood state in drug-naïve patients with bipolar disorder.
Retinal Disease in Patients With Bipolar Disorder
The eyes are a window to the brain. Researchers performed a nationwide cohort study of the risk of retinal disease in patients with bipolar disorder.
Comorbidity Before and After a Diagnosis of Schizophrenia
Researchers investigated population-level phenotypes occurring before and after diagnosis of schizophrenia using a large health insurance claims dataset.
Glucose Metabolism and Obesity in Bipolar Disorder
Researchers performed a meta-analysis of the prevalence of type 2 diabetes, impaired fasting, glucose, and general and abdominal obesity in bipolar disorder.
Metformin in Treatment-Resistant Bipolar Depression
Adjunctive metformin in bipolar disorder. Researchers performed a randomized clinical trial of treating insulin resistance to improve clinical outcomes in treatment-resistant bipolar depression.
Insomnia and Cognition in Males vs Females With Schizophrenia
“In the general population, insomnia is associated with greater cognitive impairment, but its association (and potential sexual dimorphic effect) in schizophrenia is less clear.”
Dietary Intervention for Mood Variability in Bipolar Disorder
Researchers performed a randomized controlled trial of a high n-3, low n-6 polyunsaturated fatty acid diet in bipolar disorder.
Lithium and Osteoporosis in Bipolar Disorder
Lithium for bone health? Researchers performed a retrospective cohort study to evaluate the effects of lithium on risk of osteoporosis in bipolar disorder.
Prodromal Mania and Psychosis
Predicting mania versus psychosis: Researchers performed a retrospective study of prodromal symptoms, risk factors, and vulnerability markers in first-episode mania and psychosis.
Pramipexole and Cognition in Bipolar Disorder
Researchers performed an RCT of pramipexole for patients with bipolar disorder and cognitive impairment.
Antipsychotic Nonadherence in Schizophrenia
Are you taking your medication? Researchers performed a nationwide register-based study of primary antipsychotic nonadherence in schizophrenia.
Parental Age and Risk of Bipolar Disorder
Researchers performed a systematic review and meta-analysis of paternal and maternal age and risk of bipolar disorder in the offspring.
Premature Mortality in Bipolar Disorder
Researchers performed a systematic review and meta-analysis of life expectancy and years of potential life lost in bipolar disorder.