Subthreshold Bipolarity, Low-Dose Lithium, and Non-Drug Options for Complex Depressions

Like Greek mythology’s Jason navigating between Scylla and Charybdis, (the original “rock and a hard place”), clinicians must find the narrow passage between overdiagnosis, with its risks of stigmatization and sometimes use of high-risk treatments; and underdiagnosis, where the default diagnosis of Major Depression can lead to antidepressants, mixed states, and suicidality.