
- Vol 38, Issue 12 Sleep Supplement
Is Insomnia a Predictor of Mental Illness?
A quote attributed to Benjamin Franklin is “An ounce of prevention is worth a pound of cure.” With that in mind, the field of psychiatry continues to aim to identify early indications of mental illness to initiate early treatment, since expedient treatment has been shown to positively affect the outcomes of many psychiatric disorders. Indeed, there is an unmet need for preventive strategies that delay or forestall the onset of mental illness, particularly in persons at heightened risk. Consequently, researchers have looked at insomnia—a syndrome with chronic problems related to sleep onset and/or continuity that are associated with impaired
Hertenstein and colleagues3 performed a systematic, quantitative review of longitudinal studies, investigating whether baseline
Longitudinal studies were included if they met the following criteria: follow-up lasted at least 12 months for adults in whom
The authors identified 13 studies, comprising a total sample of 181,798 participants at baseline and 133,967 at the last follow-up. These studies included 10 samples for depression, 6 for anxiety, 2 for
Across all studies pooled together, baseline insomnia was associated with a significant, 2.6-fold increased odds of mental disorder, with evidence of significant between-study heterogeneity. Overall, the risk of bias was rated as moderate for most individual studies. There was no significant evidence of publication bias for either depression or anxiety. There was no evidence that study duration moderated these associations. Furthermore, the pattern of findings did not change in a subgroup analysis of studies of participants without any mental disorders at baseline.
The authors concluded that baseline insomnia is associated with significantly increased odds of incident mental disorder. Potential explanations for these associations include brain
Dr Miller is a professor in the Department of Psychiatry and Health Behavior, Augusta University, Augusta, Georgia. He is the schizophrenia section chief for Psychiatric Times™. The author reports that he receives research support from Augusta University, the National Institute of Mental Health, the Brain and Behavior Research Foundation, and the Stanley Medical Research Institute.
References
1. Baglioni C, Battagliese G, Feige B, et al.
J Affect Disord. 2011;135(1-3):10-19.
2. Li L, Wu C, Gan Y, et al.
3. Hertenstein E, Feige B, Gmeiner T, et al.
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