Noninvasive Brain Stimulation in the Treatment of Acquired Brain Injury


Noninvasive brain stimulation techniques have been shown to be safe and effective in treating the cognitive, physical, and emotional consequences of acquired brain injury.



According to the Brain Injury Association of America, an acquired brain injury (ABI) is an injury to the brain, which is not congenital, hereditary, degenerative, or caused by birth trauma.1 A nontraumatic brain injury is caused by an illness or disease that affects the brain and brain function.2 National surveillance data indicates there are approximately 3 million new cases of ABI each year in the United States, most from traumatic brain injuries and stroke.3,4 

ABI can result in multiple and complex changes in several domains, including physical/somatic, cognitive, emotional, and behavioral.5 Physical or somatic consequences can include headache, balance disturbance, motor/movement disorders, fatigue, and sensory changes. Cognitive complaints that frequently accompany ABI include decreased attention/concentration, poor memory, executive dysfunction, and subtle language difficulties (such as naming and word-finding problems). Frequently reported emotional and behavioral problems include anxiety, depression, irritability, agitation, and sometimes, aggression.5 ABI can also increase the risk for development of debilitating comorbidities, and long-term disease burden.6

A substantial number of individuals with ABI require intensive rehabilitation to recover. Neurorehabilitation programs affect change in function by promoting plasticity through activity-based neurostimulation.7 Neuronal circuits are modified by experience and learning. Research has shown that experience-dependent learning can change neural circuity at multiple levels of the central nervous system, including synapses, cortical maps, and larger neural networks.8,9 While the effectiveness of neurorehabilitation is well documented, there is wide variability of therapeutic interventions, inconsistencies in frequency and duration of treatment, and poor adherence to published guidelines and best practice recommendations.10 Neuronal modulation and activity is therefore difficult to control and neuronal repair is difficult to measure in individuals receiving activity-based neurorehabilitation.7

Additionally, some treatments for the consequences of ABI—particularly pharmacological treatment for mood disorders, cognitive dysfunction, and motor/movement disorders—can cause adverse effects.11 Noninvasive brain stimulation has been shown to be a safe, effective treatment following ABI, allowing for greater control of neuromodulation with minimal adverse effects. Two methods of noninvasive brain stimulation, transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS), have been used to treat mood disorders, cognitive deficits, and motor disorders following TBI and stroke.12,13 

Repetitive Transcranial Magnetic Stimulation

rTMS is a neuromodulator tool used to regulate neural activity through the use of rapidly alternating magnetic fields. A magnetic pulse passes through the skull and induces activity in a targeted (ie, focal) cortical region. Pulses can be delivered repetitively to produce long-term changes in neural activity. Cortical excitability can be upregulated through the application of high-frequency stimulation (>5 Hz), or downregulated with low-frequency stimulation (~1 Hz).14

Hummel and colleagues noted an interhemispheric imbalance in patients with brain injury and noninvasive brain stimulation can reduce the imbalance.15 High frequency stimulation of an affected hemisphere increases cortical excitability, whereas low frequency stimulation of an unaffected hemisphere decreases cortical excitability. rTMS has been shown to be safe and risks of adverse effects are low when established guidelines are followed. Common adverse effects of rTMS include headache and minor scalp irritation following therapy, but these tend to be transient. Though rarely reported in the literature, there is an increased risk for seizure activity in persons with brain injury, requiring additional monitoring or management via strict criteria for inclusion in treatment.16

Transcranial Direct Current Stimulation

tDCS is another noninvasive neuromodulator tool that uses low amplitude direct current, usually 1 to 2 milliamps, to alter cortical excitability. tDCS regulates cortical excitability by altering neuronal resting membrane potentials, increasing the likelihood of depolarization (increasing cortical excitability) or hyperpolarization (decreasing cortical excitability). An anode and cathode electrodes are placed over the head. Anodal tDCS increases underlying cortical excitability, while cathodal tDCS decreases underlying cortical excitability.17 As with rTMS, the administration of tDCS is safe and effective. Adverse effects, such as moderate fatigue, mild headache, nausea, and itching at the area of stimulation, are infrequent and transient. According to Nitsche and colleagues, the risk for seizures is essentially absent for individuals without a history of epilepsy.18

Use and Effectiveness in Rehabilitation Following Acquired Brain Injury

Neuromodular techniques, such as rTMS and tDCS can be administered as monotherapy, but may produce better clinical outcomes when combined with other therapeutic interventions, such as cognitive rehabilitation, physical therapy, and psychotherapy.19

Zaninotto and colleagues reviewed the literature on the effects of tDCS on recovery following TBI. While results were mixed, the authors reported that in most studies, tDCS improved responsiveness in patients with disorders of consciousness; improved cognitive function, particularly when tDCS was paired with cognitive rehabilitation; and improved motor recovery when paired with physical therapy. Anodal stimulation and electrode placement were consistent in all studies (ie, left dorsolateral prefrontal cortex). However, large variability was noted in stimulation parameters, the number of tDCS sessions, and pairing with additional therapies.These methodological differences may account for mixed results.

Lee and Kim investigated the use of low frequency rTMS to treat depression and cognitive deficits in patients with TBI using a randomized controlled design.13 Participants were randomly assigned to an experimental or control group. Measurements of depressive symptoms and cognitive function were administered before any rTMS interventions and again following the 10 sessions of rTMS. All participants received neurodevelopmental therapy (NDT) for muscle strengthening and movement reeducation. Following NDT sessions, participants in the experimental group received low frequency stimulation applied to the right dorsolateral prefrontal cortex once per day, 5 times per week for 2 weeks, weekends excluded. Participants in the control group received “sham” rTMS; participants were placed in the stimulator chair and the coil was placed over the right dorsolateral prefrontal cortex, but no magnetic pulse was delivered. Compared to controls, participants in the experimental group showed improvement in depressive symptoms (Montgomery-Asberg Depression Rating Scale), and cognitive performance (Trail Making Test and Stroop Color Word Test).

rTMS has also been used to treat language deficits (improvements noted in naming accuracy, word repetition), visuospatial neglect (improvements noted in line bisection and clock drawing task), and executive functioning in individuals with TBI or stroke.20-22

Concluding Thoughts

Noninvasive brain stimulation techniques, such as rTMS and tDCS have been shown to be safe and effective in treating the cognitive, physical, and emotional consequences following acquired brain injury. rTMS and tDCS allow for controlled and targeted neuromodulation, and when combined with other therapeutic approaches—such as physical therapy, occupational therapy, speech/language therapy, and psychotherapy—may produce superior outcomes. Noninvasive brain stimulation techniques may be a suitable alternative to treatments that can cause deleterious adverse effects following ABI.

Dr Seale is the regional director of clinical services at the Centre for Neuro Skills, which operates post-acute brain injury rehabilitation programs in California and Texas. He is licensed in Texas as a chemical dependency counselor and psychological associate with independent practice. He also holds a clinical appointment at the University of Texas Medical Branch (UTMB) in Galveston in the Department of Rehabilitation Sciences.


1. What is the difference between acquired brain injury and traumatic brain injury? Brain Injury Association of America. Accessed November 10, 2022.

2. Definition of acquired brain injury. Toronto Acquired Brain Injury Network. March 31, 2005. Accessed November 10, 2022.

3. Report to Congress on Traumatic Brain Injury in the United States: Epidemiology and Rehabilitation. Centers for Disease Control and Prevention; National Center for Injury Prevention and Control; Division of Unintentional Injury Prevention. 2015. Accessed November 10, 2022.

4. Stroke. Centers for Disease Control and Prevention. 2021. Accessed November 10, 2022.

5. Greenwald BD, Burnett DM, Miller MA. Brain injury: epidemiology and pathophysiology. Arch Phys Med Rehabil. 2003;84(3 Suppl 1):S3-S7.

6. Masel BE, DeWitt DS. Traumatic brain injury: a disease process, not an event. J Neurotrauma. 2010;27(8):1529-1540.

7. Roger J, Sherrard RM. Optimising repetitive transcranial magnetic stimulation for neural circuit repair following traumatic brain injury. Neural Regen Res. 2015;10(3):357-359.

8. Kimberley TJ, Samargia S, Moore LG, et al. Comparison of amounts and types of practice during rehabilitation for traumatic brain injury and stroke. J Rehabil Res Dev. 2010;47:851-862.

9. Kelly C, Foxe JJ & Garavan H. Patterns of normal human brain plasticity after practice and their implications for neurorehabilitation. Arch Phys Med Rehabil. 2006;87(12 Suppl 2):20-29.

10. Teasell R, Bayona N, Marshall S, et al. A systematic review of the rehabilitation of moderate to severe acquired brain injuries. Brain Inj. 2007;21(2):107-112.

11. Fann JR, Hart T, Schomer KG. Treatment for depression after traumatic brain injury: a systematic review. J Neurotrauma. 2009;26(12):2383-23402.

12. Lee SA, Kim MK. Effect of low frequency repetitive transcranial magnetic stimulation on depression and cognition of patients with traumatic brain injury: a randomized controlled trial. Med Sci Monit. 2018;24:8789.

13. Kim WS, Lee K, Kim S, et al. Transcranial direct current stimulation for the treatment of motor impairment following traumatic brain injury. J Neuroeng Rehabil. 2019;16(1):14.

14. Ross S, Hallett M, Rossini PM, et al. Safety, ethical considerations and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research. Clin Neurophysiol. 2009;120(12):2008-2039.

15. Hummel FC, Cohen LG. Non-invasive brain injury stimulation: a new strategy to improve neurorehabilitation after stroke? Lancet Neurol. 2006;5(8):708-712.

16. Kletzel SL, Aaronson AL, Guernon A, et al. Safety considerations for the use of transcranial magnetic stimulation as treatment for coma recovery in people with severe traumatic brain injury. J Head Trauma Rehabil. 2020;35(6):430-438.

17. Nitsche MA, Liebetanz D, Lang N, et al. Safety criteria for transcranial direct current stimulation (tDCS) in humans. Clin Neurophysiol. 2003;114(11):2220-2222.

18. Nitsche MA, Cohen LG, Wassermann EM, et al. Transcranial direct current stimulation: state of the art 2008. Brain Stimul. 2008;1(3):206-223.

19. Zaninotto AL, El-Hagrassy MM, Green JR, et al. Transcranial direct current stimulation (tDCS) effects on traumatic brain injury (TBI) recovery: a systematic review. Dement Neuropsychol. 2019;13(2):172-179.

20. Barwood CH, Murdoch BE, Whelan BM, et al. The effects of low frequency repetitive transcranial magnetic stimulation (rTMS) and sham condition rTMS on behavioral language in chronic non-fluent aphasia: short-term outcomes. NeuroRehabilitation. 2011;28(2):113-128.

21. Lim JY, Kang EK, Paik NJ. Repetitive transcranial magnetic stimulation to hemispatial neglect in patients after stroke: an open-label pilot study. J Rehabil Med. 2010;42(5):447-452.

22. Hara T, Abo M, Sasaki N, et al. Improvement of higher brain dysfunction after brain injury by repetitive transcranial magnetic stimulation and intensive rehabilitation therapy: case report. Neuroreport. 2017;28(13):800-807.

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