Author | John J. Medina, PhD


The Molecular Biology of Weight Loss: An Unexpected Linkage Between 2 Molecules

February 08, 2012


This article outline a previously undescribed mechanism for understanding the molecular relationships between the hypothalamus and high-fat diets. Do they also hint at the creation of a fat pill?

Modeling Schizophrenia: An In Vitro Model of a Tough Disease

October 06, 2011


This column has always been about the world of molecular mental health research. I revisit the technology in this column, now aimed at one of molecular neuropsychiatry’s most intractable, frustrating lines of research: the molecular/cellular basis of schizophrenia.

Lorenzo’s Oil and the Rehabilitation of Gene Therapy

June 09, 2011


Gene therapy (sometimes called gene replacement therapy) attempts to ameliorate genetic-based disorders by introducing corrected genes into affected patients.

Custom-Made Neural Stem Cells

May 04, 2011


In this column, we explore how the judicious use of neural stem cells (NSCs) has led to a research Holy Grail: the creation of research-ready, patient-specific neurons.

To Sirtuin With Love: Caloric Restrictions and the Genes of the Aging Brain

April 06, 2011


One of the most remarkable discoveries in the field of life span alteration occurred in the past century and has to do with caloric restriction.

The Neurobiology of Conscious Intent

February 10, 2011


Pushing the edge of our understanding into the murky world of association cortex only means that future experiments will be trickier to interpret.

The Business of Pleasure and Pain

December 02, 2010


The neuroanatomical linkage that emerges from a normal part of business experience-the reaction to success and also to failure (especially if that failure happens to someone else)-is the focus of this column.

Elegant Knockdowns, DISC1, and Schizophrenia

June 03, 2010


When I was a grad student-back in the Jurassic Era of molecular manipulations-my lab mates and I were all transfixed by the notion of a new technology: knockout animals (KOAs). This was because of its promise to solve a vexing problem.

Memory Reconsolidation and What Albert Ellis Knew All Along

May 12, 2010


I can almost hear Albert Ellis saying “Amen” to the data I am about to share. To explain his reaction, I have to talk about war.

The Epigenetics of Stress

April 07, 2010


Overly sensitive, aversive reactions to stress seem to run in families. The literature abounds with reports of relatives in these populations predisposed to depression, anxiety, and even suicide. Some family members present with glucocorticoid levels notched abnormally high, and in curiously deregulated concentrations. Behaviorally, they seem to exist at a permanent state of high alert.