September 10th 2025
Takeda's oveporexton shows promising results in treating narcolepsy type 1, significantly improving symptoms and quality of life in clinical trials.
Sleep Disturbances After Traumatic Brain Injury
September 30th 2015Sleep-related problems are among the most disabling consequences of TBI, with multiple influences: impairment of neuronal plasticity, metabolomic alterations, loss of vascular homeostasis, and disruption of the blood-brain barrier. The authors take a close look.
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Tipsheet: Sleep Disturbances in Psychiatric Illness
August 1st 2014Most patients with psychiatric diagnoses present with sleep disturbances that can have as great an impact on health-related quality of life as the mental illness itself. Here are tips on treatment and chronotherapeutic applications for major depression and other disorders.
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Depression and Restless Legs Syndrome
April 9th 2014Depression is a frequent psychiatric comorbidity among patients with restless leg syndrome. The case presented here illustrates the importance of evaluating for RLS symptoms in patients with major depressive disorder who complain of insomnia.
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Clinical Features of Sleep-Disordered Breathing
February 4th 2014Sleep-disordered breathing signs and symptoms overlap with mood, anxiety, and other psychiatric illnesses. In some cases, they may masquerade as these disorders, but SDB can also provoke and/or exacerbate other psychiatric conditions. Signs, risk factors, and clinical features in this Tipsheet.
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Reset Your Inner Clock: The Drug-Free Way to Your Best-Ever Sleep, Mood, and Energy
January 9th 2014A book that may help doctors, as well as their patients, better understand how they tick, literally, in our 24/7 society, and find a balance between difficult temporal demands and somatic and mental health.
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Catching Up on Sleep: From Comorbidity to Pharmacotherapy
August 26th 2013More than half of all patients with psychiatric disorders report disturbances of sleep and wakefulness. "Sleep disorders are associated with impaired daytime function and predict a heightened future vulnerability to psychiatric disease. They also diminish life span.” Details from an expert here.
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Characteristics of Sleep Disorders in Women
July 19th 2013This brief review addresses what is currently known about sleep problems in women. The main focus is on sleep issues that are particularly relevant to reproductive stages in a woman’s life cycle and therefore potentially linked to reproductive and/or hormonal factors.
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Pediatric Major Depressive Disorder: Questions to Consider
November 16th 2012What are the options for treating major depressive disorder in children and adolescents? This case offers readers a chance to give their feedback and to interact with the authors, who will present teaching points based on your comments.
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The Effects of Antidepressants on Sleep
June 13th 2012Knowledge of how different antidepressants are likely to affect parameters of sleep can provide an important basis for selecting an appropriate antidepressant drug among the roughly 2 dozen marketed options to meet the needs of depressed patients.
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ADHD and Sleep Disorders in Children
June 13th 2012Sleep changes associated with psychotropic drugs are common enough to justify routinely obtaining a baseline sleep diary before beginning treatment, even when the initial screening for sleep disorders indicates that no further investigation is needed.
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Are a history of complicated pneumonia and possible obstructive sleep apnea part of the DSM-IV exclusionary criteria for potential participants in anesthesia-assisted opioid withdrawal? How many alcoholic drinks a week does it take for a woman to be considered an at-risk drinker? These and more in this week's quiz.
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During my medical training in the early 1980s, I attended a Grand Rounds on health care reform. Sleep-deprived physicians-in-training are easily conditioned to snooze upright in their auditorium seats, and economics is not an interest of choice for me, but when the speaker told us that there would be no solution to rising health care costs except to fracture the bond between patient and doctor, I found myself engaging in nightmarish fantasies that in subsequent decades have come true.
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