Gus Alva, MD, DFAPA; Carmen Kosicek, MSN, PMHNP-BC; and Roger McIntyre, MD, FRCPC wrap up the conversation discussing optimizing treatment response with a focus on rapid-acting antidepressants (ADTs), including real-world patient responses and clinical study data. They address patient education, treatment expectations, titration, and follow-up strategies to enhance treatment optimization and outcomes.
The authors of the Clinician's Corner column discuss the latest FDA-approved treatment for schizophrenia.
A panel of mood disorder experts explore the challenges of treatment-resistant depression (TRD), including defining TRD, managing partial improvement, and addressing adverse reactions. They discuss the role of glutamate in TRD, efficacy and safety considerations from clinical trials, treatment half-life, and real-world experiences with pharmacovigilance.
Experts in the management of depression discuss managing unsatisfactory responses in chronic MDD, focusing on anhedonia and its role in disability. They explore strategies to improve treatment outcomes and address the persistent challenges faced by patients with chronic depressive symptoms.
Gus Alva, MD, DFAPA; Carmen Kosicek, MSN, PMHNP-BC; and Roger McIntyre, MD, FRCPC delve into FDA-approved rapid-acting treatments for MDD and TRD, focusing on the sigma-1 agonist and its pharmacodynamics. They explore treatment indications, the rapid onset of action, and how these innovations address unmet clinical needs and shift the treatment paradigm for newly diagnosed depression
Experts in the management of mood disorders discuss the challenges of treatment failure and achieving symptomatic remission in MDD. They examine the efficacy of antidepressant and rapid-acting treatments, offering insights into evaluating and enhancing treatment outcomes.
Gus Alva, MD, DFAPA presents the case of a patient with recurrent MDD, and the panel explores treatment approaches, comments on the condition triggers, and challenges in managing persistent depression.
Experts in affective disorders discuss the pathophysiology, genetic components, and neurocircuitry involved in these conditions. They delve into treatment nomenclature and patient conversations, focusing on how to target specific brain areas, assess responses, and manage treatments to improve quality of life and hedonic tone
Experts in the management of depression provide insights into understanding medication mechanisms, assessing when treatments are effective, and navigating therapy adjustments to optimize outcomes and complement various MOAs
Carmen Kosicek, MSN, PMHNP-BC shares her insights into insurance coverage, the role of specialty pharmacies, and patient advocacy efforts to improve access to novel MDD therapies.
Experts in the management of mood disorders comment on how to assess and quantify treatment response in MDD, focusing on effective measurement strategies to guide clinical decisions
A patient suffering from MDD, shares his story and the rapid benefits of patient experience with NMDA-targeted therapy, commenting on the tremendous quality of life benefit.
Gus Alva, MD, DFAPA; Carmen Kosicek, MSN, PMHNP-BC; and Roger McIntyre, MD, FRCPC, focus on social determinants of health and MDD commenting on treatment augmentation, and integrative approaches like social prescribing.
A panel of depressive disorder experts examines the need for updated APA treatment guidelines related to major depressive disorder, highlighting the roles of pharmacotherapy, psychotherapy, and combination therapy based on severity.
Experts in the management of mood disorders comment on the evolving management of major depressive disorder, emphasizing findings from the STAR*D trial, updated treatment guidelines, and the role of precision medicine and the shift toward personalized, rapid-acting treatments to improve patient outcomes.
Gus Alva, MD, DFAPA, introduces his esteemed colleagues and leads a comprehensive discussion on the complexities of managing major depressive disorder. The conversation addresses the rising prevalence of MDD, the enduring stigma surrounding the condition, and its profound impact on patient quality of life.
John J. Miller, MD, discusses the risks of untreated PTSD and the importance of implementing more therapeutic tools into treatment paradigms.
Addressing the importance of safe treatments for PTSD, Dr John Miller discusses adverse effect management practices and the role of REMS protocols.
Focusing on the future of PTSD treatment, Dr John Miller outlines how novel treatments can address current challenges and unmet needs in the therapeutic landscape.
John J. Miller, MD, provides an overview of the symptom clusters of PTSD and treatments that are being looked at to improve patient care.
The Psychiatric Times editor-in-chief shares perspectives on how a novel treatment, MDMA-assisted therapy, can potentially change the treatment landscape and improve patients’ lives.
John J. Miller, MD, discusses how the diagnosis and treatment of posttraumatic stress disorder (PTSD) has evolved over time.
Karl Doghramji, MD, FAASM, DFAPA, and Chelsie Monroe, MSN, APN, PMHNP-BC, conclude the discussion with advice for clinicians who treat patients with narcolepsy.
Experts on narcolepsy offer perspectives on non-pharmacologic interventions for pediatric patients with narcolepsy, including lifestyle changes.
Focusing on the case of a 9-year-old with excessive daytime sleepiness and sudden episodes of muscle weakness, the panel discusses the difficulty in diagnosing pediatric patients with narcolepsy.
Building upon the discussion of a complex case of a patient with narcolepsy, the panel provides clinical insights on cotreatment practices.
Chelsie Monroe, MSN, APN, PMHNP-BC, and Karl Doghramji, MD, FAASM, DFAPA, discuss the complex case of a 23-year-old man who presents with excessive daytime sleepiness, cataplexy, hallucinations, and episodes of neurocardiogenic syncope.
The panel offers comprehensive insights on adapting narcolepsy treatments for patients who experience adverse effects, achieve partial response, or have a history of substance abuse.
Experts on narcolepsy discuss review the case of a 35-year-old woman with excessive daytime sleepiness and hypnagogic hallucinations and offer their clinical insights on treatment strategies.
