Racial, Ethnic Variables Shape the Experience of Chronic Pain

November 1, 2006
Jordana Bieze Foster

That depression, anxiety, sleep disorders, and other neuropsychological conditions are often associated with chronic pain isn't news to most neurologists. But physicians who do not specialize in pain management are largely unaware of a growing body of research suggesting that the race (a genetic classification) or ethnicity (a cultural classification) of a patient with chronic pain may determine the patient's risk of neuropsychological symptoms.

That depression, anxiety, sleep disorders, and other neuropsychological conditions are often associated with chronic pain isn't news to most neurologists. But physicians who do not specialize in pain management are largely unaware of a growing body of research suggesting that the race (a genetic classification) or ethnicity (a cultural classification) of a patient with chronic pain may determine the patient's risk of neuropsychological symptoms.

Apparent contradictions between laboratory results and population-based study findings suggest that racial or ethnic variations in the pain experience--the ways in which chronic pain affects a patient's quality of life--may be as important clinically as racial or ethnic differences in pain tolerance. However, some relationships that appear to have a racial or ethnic basis may in fact be more grounded in socioeconomic or cultural factors. These factors may be more difficult for a clinician to ascertain.

Researchers are beginning to piece together the race-pain puzzle, as evidenced by the increasing numbers of studies being presented at American Pain Society (APS) meetings and published in the medical literature. Much of what investigators are learning, how- ever, has yet to trickle down to the treating physician.

"With great efforts by the American Pain Society as well as others, more and more pain physicians are becoming increasingly aware of race/ethnicity as a factor in the management of pain," said Charles E. Argoff, MD, director of the Cohn Pain Management Center at North Shore University Hospital on Long Island, New York, and assistant professor of neurology at New York University. "Non-pain physicians also need to be more aware of this, and I think much more work needs to be done here as well."

TESTING FOR TOLERANCE

In trying to understand the relationship between race and pain, one of the most basic questions researchers have been asking is whether patients of different racial backgrounds have different levels of pain tolerance and pain sensitivity. The answer, perhaps not surprisingly, is yes and no.

In a study of 30 white and 18 black volunteers, researchers from the University of Alabama at Birmingham found that the black participants had significantly lower thermal pain tolerance and rated the lowest of the thermal stimuli as more unpleasant than did their white counterparts; however, they found no significant racial differences in thermal pain thresholds or pain intensities.1 The findings are consistent with those of researchers from the University of Florida, who found that 62 black volunteers had lower tolerance of thermal pain, cold pressor pain, and ischemic pain than 58 white volunteers and that they also had significantly higher ratings of unpleasantness and intensity for suprathreshold thermal pain.2

British investigators reported that 20 South Asian male volunteers had significantly lower thermal pain thresholds and experienced higher pain intensity than 20 white men, but found no statistically significant group differences for cold pain threshold or heat unpleasantness.3 Meanwhile, Danish researchers found significantly greater levels of pain intensity following capsaicin injection to the forehead (to induce migraine-like trigeminal sensitization) in 16 South Indian male volunteers than in 16 white volunteers; the size of the hyperalgesic area was also significantly larger in the South Indian subjects.4

REAL-WORLD RESULTS

Outside the laboratory, however, researchers have reached conflicting conclusions regarding ethnic and racial differences in pain intensity and pain severity.

In a study of 712 patients with chronic pain presented at the 2004 meeting of the APS, researchers from the Haley Veteran's Affairs Medical Center in Tampa, Florida, reported that pain intensity ratings in Hispanic and black patients were significantly higher than in white patients, although ratings for the 2 ethnic minority groups did not differ significantly from each other.5 In addition, researchers from the University of Chicago found that 57 black patients with chronic pain had higher levels of pain severity than 207 white patients.6

However, separate studies from Arizona State University (ASU)7 and Johns Hopkins University8 found no such ethnic discrepancies. The ASU researchers found no significant difference in pain severity between 214 black patients and 214 white patients with chronic pain. The Johns Hopkins investigators found that neither pain severity nor pain intensity differed significantly between groups of black, Hispanic, and white patients with chronic pain.

COMORBIDITY COMPLEXITY

Research has been similarly inconsistent in its ability to conclusively link race or ethnicity to the risk of depression, anxiety, or other neuropsychological comorbidities. Some studies have demonstrated significant independent associations and others have found that racial and ethnic variables are inextricably linked to socioeconomic ones.

Investigators from the Houston Veterans Affairs Medical Center found significantly higher levels of depression in 128 black patients with chronic pain than in 354 white patients, even after controlling for pain severity.9 But the aforementioned Johns Hopkins study,8 which closely matched subjects for such confounding variables as education, work status, and pain duration, found no significant differences between black, Hispanic, and white patients in terms of depression scale scores. Researchers from Florida State University did not find that depression was independently associated with ethnicity, but did find that ethnic differences in pain reports were exacerbated by depression, such that the difference in pain reports be- tween Hispanic and white patients with depression was greater than the difference between Hispanic and white patients who were not depressed.10

Carmen R. Green, MD, associate professor of anesthesiology and a pain medicine physician at the University of Michigan, has seen such apparent contradictions in her own research. In a 2003 study pre- sented at the APS meeting, Green and colleagues found that black women with chronic pain not only had lower levels of pain but also were more likely than white women to experience depression or post-traumatic stress disorder.11 In a 5750-patient study presented at the following year's APS meeting, they found that black persons with chronic pain had significantly more difficulty with falling asleep and reported worse overall sleep quality than their white counterparts.12

In 3 studies presented in May at this year's APS meeting, however, Green and colleagues found that increased risk of depression in black men with chronic pain was due in large part to socioeconomic disadvantage.13-15 Looking specifically at patients aged 50 years and older, they found that although race was not associated with mood disorders, it was associated with lower socioeconomic status, which in turn was associated with a higher risk of mood disorders.14 In a 2834-patient study, the relationship between race and emotional disorders was mediated by neighborhood advantage (the percentages of residents with a college degree, of annual household incomes above $100,000, and of owner-occupied households) while race was found to be significantly associated with psychotic disorders independent of neighborhood disadvantage (the percentages of unemployment, of residents without a high school education, and of annual household incomes below $5000).15

PINPOINTING DISABILITY

The common denominator, according to Green, is disability: those whose lives are disrupted to the greatest extent by chronic pain are most at risk for comorbidities. Her group's studies consistently show that black persons with chronic pain experience greater levels of disability than their white counterparts.11,13-17 "Depression is mediated through disability, so if you can control for that then the risk of depression does not increase," Green said.

The Johns Hopkins researchers,8 who found no significant between-group differences in disability levels, surmised that the apparent discrepancy between their findings and those of other researchers was probably due to the extent to which they controlled for confounding variables. To that end, the University of Chicago researchers also found significantly greater levels of disability in black patients with chronic pain than in white patients; however, they also found that this significance disappeared when pain severity was controlled for.6 But the Johns Hopkins researchers also acknowledged that some of the disparities between their findings and those of others may stem from the use of different assessment tools. Specifically with regard to disability, they found no significant between-group differences using the Multidimensional Pain Inventory but previously had found significant differ- ences using the Oswestry Disability Questionnaire18; Green and colleagues use the Pain Disability Index.

"People often believe that once you control for socioeconomic status, some of these racial differences will go away," Green said. "That's not consistent with the literature. The differences may narrow, but they do not go away."

CLINICAL IMPLICATIONS

That said, Green and others believe that it is important for clinicians to consider a patient's socioeconomic status and the circumstances under which he or she lives when determining treatment strategies for chronic pain. If the patient is the sole caretaker in his household, the stress of maintaining care can exacerbate the stress of living with chronic pain. For ethnic minorities, there is the added stress of racial discrimination to consider as well.

Previous research suggests that ethnic minorities may be less likely to seek treatment for their pain, whether through self-care or from a physician.19-22 "A lot of people have the mistaken belief that 'I don't want to bother the doctor, and that if I do it will take his or her attention away from my cancer or my other problems,'" Green said. "That's something we see in particular in our minority population. They cope better but they feel they have less control over their pain."

The Johns Hopkins study, while finding no statistically significant ethnic differences for most coping variables, did find that black and Hispanic patients with chronic pain were more likely than white patients to use prayer as a coping strategy--and that use of prayer was predictive of greater disability across all 3 ethnic groups.8

"Cultural, ethnic, and socioeconomic influences can contribute to a patient's belief system, which will affect the neurologist-patient relationship and the patient's compliance, trust, and response to future treatment," said Peter Lars Jacobson, MD, clinical pro- fessor of neurology and director of the Palliative Care Program at the University of North Carolina in Chapel Hill. "A detailed past social history including previous experiences with physicians, thoughts about past treatments--both positive and negative--and possible future therapies would help to identify important racial and ethnic components that should be incorporated into a successful treatment plan."

Experts also agree that clinicians should be vigilant in diagnosing and treating neuropsychological symptoms in all patients with chronic pain, regardless of race or ethnicity. "Clinically, all patients with chronic pain need to be assessed for neuropsychological comorbidities including depression, post-traumatic stress disorder, sleep disorders, and previous history of alcohol or drug dependence," Jacobson said. "The treatment plan needs to approach these comorbidities to be comprehensive and effective."

REFERENCES1. Edwards RR, Fillingim RB. Ethnic differences in thermal pain responses. Psychosom Med. 1999;61:346-354.
2. Campbell CM, Edwards RR, Fillingim RB. Ethnic differences in response to multiple experimental pain stimuli. Pain. 2005;113:20-26.
3. Watson PJ, Latif RK, Rowbotham DJ. Ethnic differences in thermal pain responses: a comparison of South Asian and White British healthy males. Pain. 2005;118:194-200.
4. Gazerani P, Arendt-Nielsen L. The impact of ethnic differences in response to capsaicin-induced trigeminal sensitization. Pain. 2005;117:223-229.
5. Young R, Clark M, Gironda R. Racial group differences in chronic pain treatment outcomes. Paper presented at: Annual Scientific Meeting of the American Pain Society; May 6-9, 2004; Vancouver, British Columbia.
6. McCracken LM, Matthews AK, Tang TS, Cuba SL. A comparison of blacks and whites seeking treatment for chronic pain. Clin J Pain. 2001;17:249-255.
7. Ruehlman LS, Karoly P, Newton C. Comparing the experiential and psychosocial dimensions of chronic pain in African Americans and Caucasians: findings from a national community sample. Pain Med. 2005;6:49-60.
8. Edwards RR, Moric M, Husfeldt B, et al. Ethnic similarities and differences in the chronic pain experience: a comparison of African American, Hispanic, and white patients. Pain Med. 2005;6:88-98.
9. Tan G, Jensen MP, Thornby J, Anderson KO. Ethnicity, control appraisal, coping, and adjustment to chronic pain among black and white Americans. Pain Med. 2005;6:18-28.
10. Hernandez A, Sachs-Ericsson N. Ethnic differences in pain reports and the moderating role of depression in a community sample of Hispanic and Caucasian participants with serious health problems. Psychosom Med. 2006;68: 121-128.
11. Green C, Baker T, Nagrant A. The impact of race and ethnicity upon women presenting for chronic pain management. Paper presented at: Annual Scientific Meeting of the American Pain Society; March 20-23, 2003; Chicago.
12. Green C, Lin X, Ndao-Brumblay S. Sleep quality in black and Caucasian Americans with chronic pain. Paper presented at: Annual Scientific Meeting of the American Pain Society; May 6-9, 2004; Vancouver, British Columbia.
13. Green C, Ndao-Brumblay S, Hart-Johnson T. Chronic pain determinants in black and white men upon initial assessment. Paper presented at: Annual Scientific Meeting of the American Pain Society; May 3-6, 2006; San Antonio, Tex.
14. Green C, Fuentes M. Association between race, neighborhood SES and chronic pain in black and white elders. Paper presented at: Annual Scientific Meeting of the American Pain Society; May 3-6, 2006; San Antonio, Tex.
15. Green C, Hart-Johnson T, Ndao-Brumblay S. The association of race, disadvantage and advantage and the effects on chronic pain. Paper presented at: Annual Scientific Meeting of the American Pain Society; May 3-6, 2006; San Antonio, Tex.
16. Ndao-Brumblay S, Hart-Johnson T, Miller M, et al. Health outcomes, QOL, and disability among working age Black and White adult persons with chronic pain. Paper presented at: Annual Scientific Meeting of the American Pain Society; March 30-April 2, 2005; Boston.
17. Green CR, Laporte F, Baker T, et al. Impact of race and ethnicity on the chronic pain experience of young adults. Paper presented at: Annual Scientific Meeting of the American Pain Society; March 14-17, 2002; Baltimore, Md.
18. Edwards RR, Doleys DM, Fillingim RB, Lowery D. Ethnic differences in pain tolerance: clinical implications in a chronic pain population. Psychosom Med. 2001;63:316-323.
19. Richards SB, Funk M, Milner KA. Differences between blacks and whites with coronary heart disease in initial symptoms and in delay seeking care. Am J Crit Care. 2000;9:237-244.
20. Carey TS, Evans AT, Hadler NM, et al. Acute severe low back pain. A population- based study of prevalence and care-seeking. Spine. 1996;21:339-344.
21. Green C, Baker T, Washington T. Health care attitudes and utilization in chronic pain patients: a comparison of African and Caucasian Americans. Paper presented at: Annual Scientific Meeting of the American Pain Society; March 20-23, 2003; Chicago.
22. Fisher J, Riley J. Pain disparities: race-ethnic differences in orofacial pain related dental visits. Paper presented at: Annual Scientific Meeting of the American Pain Society; May 3-6, 2006; San Antonio, Tex.