Anxiety Disorders With Comorbid Substance AbuseByEric L. Scott, PhD,Leslie Hulvershorn, MD, MScSeptember 7th 2011Anxiety disorders occur in 18% to 28% of the US general population during any 12-month period. In anxiety disorder, there is a 33% to 45% 12-month prevalence rate for a comorbid substance use disorder (SUD).