Major Depressive Disorder: What Role for Adjunctive Methylfolate Therapy?

Can methylfolate play a role in the adjunctive treatment of patients with major depression?

Here to address this issue is Rakesh Jain, MD, Associate Clinical Professor in the Department of Psychiatry and Behavioral Sciences at the University of Texas Medical School in Houston.

Further ReadingPersonalized therapy of adjunctive L-methylfolate [pdf]

L-methylfolate 15 mg as Adjunctive Therapy [pdf]

 Reference
Papakostas GI, Shelton RC, Zajecka JM, et al. L-Methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials. Am J Psychiatry. 2012;169:1267-1274.

Dr Jain's financial disclosure: please click here.

Nutrition and Depression