Jose M. Rubio, MD, PhD

Can EEG microstates and brain imaging predict antipsychotic response?

Reframe psychosis as upstream glutamate-GABA circuit imbalance, with dopamine disruption downstream; muscarinic drugs reduce symptoms and boost cognition.

Motivational interviewing helps clinicians address antipsychotic ambivalence, using open-ended questions to connect LAIs or clozapine to patient goals over time.

Ending the REMS cut the paperwork, but reimbursement that ignores clozapine’s added care demands still keeps the drug from patients who could benefit.

Clinicians should keep in mind the risk-to-benefit ratio considerations before initiating polypharmacy, especially if they have patients with prescriptions inherited from several sources. Here: A summary of recommendations about the use of polypharmacy in psychotic disorders.

Which treatments have proven to be efficacious in meta-analyses as augmentation of clozapine in reducing positive symptoms of schizophrenia? The answer might surprise you.

Antipsychotic drugs are the cornerstone in the management of psychotic disorders, but most patients fail to have a “good” response in short-term trials. Alternative strategies are presented here.