How Best to Make the Switch to Clozapine

Clozapine is the “gold-standard” antipsychotic for treatment-resistant schizophrenia.

What are potential risks of antipsychotic discontinuation?

Takeuchi and colleagues[2] hypothesized that there would be no differences in efficacy or tolerability between the 2 strategies.

Study methods part 1.

Study methods part 2.

Study methods part 3.

The primary findings were significant improvements in psychopathology upon switching to clozapine.

These preliminary findings suggest that either strategy could be used by prescribers based on clinical judgment.