Bill Zafirau, MD

Delirium is characterized by an altered level of consciousness, decreased attention span, acute onset, and fluctuating course. Approximately 15% of elderly patients admitted to the hospital have delirium as a presenting or associated symptom. Delirium will develop in another 15% of elderly patients during hospitalization.	

In hospitalized patients, delirium is associated with a 10-fold increased risk of death, a 3- to 5-fold increased risk of nosocomial complications, a prolonged stay, and postacute nursing home placement.

 In addition, delirium during hospitalization predicts a poor functional recovery and an increased risk of death up to 2 years after discharge.

 Persistent delirium predicts an especially poor long-term outcome.

The causes of delirium are often multifactorial. Predisposing and precipitating factors increase a patient's risk (

 Predisposing factors are often difficult to change but are useful in identifying high-risk patients. Precipitating factors are often modifiable and offer the best opportunity for intervention.

A number of medications may precipitate delirium (

 Some experts believe that delirium is precipitated by the use of medications with a high anticholinergic burden. This condition may be exacerbated by the endogenous anticholinergic activity that occurs in persons with delirium.

Clinical diagnosis may be difficult because delirium shares features with both dementia and depression (

). A thorough history taking is especially important, with particular focus on previous cognitive difficulties, mood disorders, and a review of medications. Traditional screening devices used for depression and dementia, such as the Geriatric Depression Scale and Mini-Mental State Examination, may not yield accurate results in the setting of comorbid delirium. Tests of attention, such as the Digit Span Test, may be useful in identifying those who have a decreased attention span, a cardinal feature of delirium. Family members can often provide valuable information about a patient's baseline cognitive status.

 are the gold standard for the diagnosis of delirium (

 Alternative criteria have been developed to help clinicians and nonclinical personnel diagnose and rate the severity of delirium. The Confusion Assessment Method is commonly used in inpatient settings and is based on 

 The NEECHAM Confusion Scale is a nursing rating tool that screens for delirium, identifies patients at high risk, and assesses severity in medical inpatients.	

Delirium can take several forms. Hyperactive delirium is the most easily recognized because patients with this form often fall or interfere with care. Hyperactive delirium is characterized by psychomotor agitation, verbal aggression, disorientation, visual hallucinations, and combativeness.

Two thirds of hospitalized patients with delirium are hypoactive and hypovigilant, however. Hypoactive delirium is characterized by somnolence and a decreased attention span. Although patients with this form are often overlooked, their delirium carries an equally poor prognosis.

A patient's cognition may fluctuate between the 2 subtypes of delirium. Therefore, it is important to remain vigilant for various signs of delirium and to obtain 24-hour reports on the patient's behavior from nursing staff and family members.

Elderly patients should be assessed for risk of delirium, and efforts toward mitigating or eliminating precipitating factors should be made-especially in those patients who show signs of or who are at high risk for delirium. Nonpharmacological interventions, such as environmental modification and nursing protocols that focus on distraction, redirection, and reorientation, are the recommended first steps in prevention and treatment. A multidisciplinary, multicomponent intervention may be useful in preventing delirium.

Patients should be redirected and removed, if possible, from offending stimuli. Underlying disorders that precipitated the delirium should be treated. Recommended pharmacological agents for agitation and psychosis are listed in 

 Use benzodiazepines with caution, because they may produce agitation. Neuroleptics may cause QT prolongation, extrapyramidal adverse effects, and akathisia. In general, it is best to start with low doses and titrate as needed. Once a medication has been found effective, schedule doses for times of peak agitation (such as before medical procedures and at bedtime).	

Use physical and pharmacological restraints only when all other options have been exhausted and the patient is interfering with care that is critical to his or her well-being (such as placement of an endotracheal tube or a central line). The use of physical restraints is associated with worsening delirium, injuries from falls, and debility. Most patients with delirium can be managed without restraints in a "delirium room."

 Pharmacological treatment of hypoactive delirium has not been extensively studied. Methylphenidate may be useful for opiate-induced delirium in a hospice setting.

 Ely EW, Shintani A, Truman B, et al. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. 

 Olofsson B, Lundstrom M, Borssen B, et al. Delirium is associated with poor rehabilitation outcome in elderly patients treated for femoral neck fractures. 

 McCusker J, Cole M, Dendukuri N, et al. The course of delirium in older medical inpatients: a prospective study. 

 Marcantonio ER, Simon SE, Bergmann MA, et al. Delirium symptoms in post-acute care: prevalent, persistent, and associated with poor functional recovery. 

 Marcantonio ER, Goldman L, Orav EJ, et al. The association of intraoperative factors with the development of postoperative delirium. 

 Inouye SK, Charpentier PA. Precipitating factors for delirium in hospitalized elderly persons. Predictive model and interrelationship with baseline vulnerability. 

 Inouye SK, Viscoli CM, Horwitz RI, et al. A predictive model for delirium in hospitalized elderly medical patients based on admission characteristics. 

 Inouye SK. Prevention of delirium in hospitalized older patients: risk factors and targeted intervention strategies. 

 Breitbart W, Tremblay A, Gibson C. An open trial of olanzapine for the treatment of delirium in hospitalized cancer patients. 

Diagnostic and Statistical Manual of Mental Disorders,

. Washington, DC: American Psychiatric Press; 1994.


. Washington, DC: American Psychiatric Press; 1987.


 Lundstrom M, Edlund A, Karlsson S, et al. A multifactorial intervention program reduces the duration of delirium, length of hospitalization, and mortality in delirious patients. 

 Naughton BJ, Saltzman S, Ramadan F, et al. A multifactorial intervention to reduce prevalence of delirium and shorten hospital length of stay. 

 Mittal D, Jimerson NA, Neely EP, et al. Risperidone in the treatment of delirium: results from a prospective open-label trial. 

 Sasaki Y, Matsuyama T, Inoue S, et al. A prospective, open-label, flexible-dose study of quetiapine in the treatment of delirium. 

 Agostini JV, Leo-Summers LS, Inouye SK. Cognitive and other adverse effects of diphenhydramine use in hospitalized older patients. 

Articles

Delirium is characterized by an altered level of consciousness, decreased attention span, acute onset, and fluctuating course. Approximately 15% of elderly patients admitted to the hospital have delirium as a presenting or associated symptom. Delirium will develop in another 15% of elderly patients during hospitalization.

Troubleshooting Delirium in Elderly Inpatients

Delirium is characterized by an altered level of consciousness, decreased attention span, acute onset, and fluctuating course. About 15% of elderly patients admitted to the hospital have delirium as a presenting or associated symptom. Delirium will develop in another 15% of elderly patients during hospitalization.

In addition, delirium during hospitalization predicts a poor functional recovery and increased risk of death up to 2 years after discharge.

The causes of delirium are often multifactorial. Predisposing and precipitating factors increase a patient's risk (Table 1).

 Predisposing factors are often difficult to change but are useful in identifying high-risk patients. Precipitating factors are often modifiable and offer the opportunity for intervention.

A number of medications may precipitate delirium (Table 2).

 Some experts believe that delirium is precipitated by the use of medications with a high anticholinergic burden. This condition may be exacerbated by endogenous anticholinergic activity that occurs in persons with delirium.

Clinical diagnosis may be difficult because delirium shares features with both dementia and depression (Table 3). A thorough history taking is especially important, with particular focus on previous cognitive difficulties, mood disorders, and a review of medications. Traditional screening devices used for depression and dementia, such as the Geriatric Depression Scale and Mini-Mental State Examination, may not yield accurate results in the setting of comorbid delirium. Tests of attention, such as the Digit Span Test, may be useful in identifying those who have a decreased attention span, a cardinal feature of delirium. Family members can often provide valuable information about a patient's baseline cognitive status.

The criteria from the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), are the gold standard for diagnosis of delirium (Table 4).

 Alternative criteria have been developed to help clinicians and nonclinical personnel diagnose and rate the severity of delirium. The Confusion Assessment Method is commonly used in inpatient settings and is based on DSM-III-R criteria (Table 5).

 The NEECHAM Confusion Scale is a nursing rating tool that screens for delirium, identifies patients at high risk, and assesses severity in medical inpatients.

Delirium can take several forms. Hyperactive delirium is the most easily recognized because patients with this form often fall or interfere with care. It is characterized by psychomotor agitation, verbal aggression, disorientation, visual hallucinations, and combativeness. Two thirds of hospitalized patients with delirium are hypoactive and hypovigilant, however. Hypoactive delirium is characterized by somnolence and a decreased attention span. Although patients with this form are often overlooked, their delirium carries an equally poor prognosis.

A patient's cognition may fluctuate between the 2 subtypes of delirium. Therefore, it is important to remain vigilant for various signs of delirium and obtain 24-hour reports on the patient's behavior from nursing staff and family members.


Elderly patients should be assessed for risk of delirium, and efforts toward mitigating or eliminating precipitating factors should be made-especially in those patients who show signs of or who are at high risk for delirium. Nonpharmacologic interventions, such as environmental modification, and nursing protocols that focus on distraction, redirection, and reorientation are the recommended first steps in prevention and treatment. A multidisciplinary, multicomponent intervention may be useful in preventing delirium.


Patients should be redirected and removed, if possible, from offending stimuli. Underlying disorders that precipitated the delirium should be treated. Recommended pharmacologic agents for agitation and psychosis are listed in Table 6.

 Use benzodiazepines with caution, because they may produce agitation. Neuroleptics may cause QT prolongation, extrapyramidal adverse effects, and akathisia. In general, it is best to start with low doses and titrate as needed. Once a medication has been found effective, schedule doses for times of peak agitation (such as before medical procedures and at bedtime).

Use physical and pharmacologic restraints only when all other options have been exhausted and the patient is interfering with care that is critical to his or her well-being (such as placement of an endotracheal tube or a central line). The use of physical restraints is associated with worsening delirium, injuries from falls, and debility. Most patients with delirium can be managed without restraints in a "delirium room."

 Pharmacologic treatment of hypoactive delirium has not been extensively studied. Methylphenidate may be useful for opiate-induced delirium in a hospice setting.

Editor's Note: A version of this article was published in the February 2006 issue of Consultant. Reprinted with permission.

 Ely EW, Shintani A, Truman B, et al. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA. 2004;291:1753-1762.


 Olofsson B, Lundstrom M, Borssen B, et al. Delirium is associated with poor rehabilitation outcome in elderly patients treated for femoral neck fractures. Scand J Caring Sci. 2005;19:119-127.


 McCusker J, Cole M, Dendukuri N, et al. The course of delirium in older medical inpatients: a prospective study. J Gen Intern Med. 2003;18:696-704.


 Marcantonio ER, Simon SE, Bergmann MA, et al. Delirium symptoms in post-acute care: prevalent, persistent, and associated with poor functional recovery. J Am Geriatr Soc. 2003;51:4-9.


 Marcantonio ER, Goldman L, Orav EJ, et al. The association of intraoperative factors with the development of postoperative delirium. Am J Med. 1998;105:380-384.


 Inouye SK, Charpentier PA. Precipitating factors for delirium in hospitalized elderly persons. Predictive model and interrelationship with baseline vulnerability. JAMA. 1996;275:852-857.


 Inouye SK, Viscoli CM, Horwitz RI, et al. A predictive model for delirium in hospitalized elderly medical patients based on admission characteristics. Ann Intern Med. 1993;119:474-481.


 Inouye SK. Prevention of delirium in hospitalized older patients: risk factors and targeted intervention strategies. Ann Intern Med. 2000;32:257-263.


 Breitbart W, Tremblay A, Gibson C. An open trial of olanzapine for the treatment of delirium in hospitalized cancer patients. Psychosomatics. 2002;43: 175-182.


 Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV). Washington, DC: American Psychiatric Association; 1994.


 Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised (DSM-III-R). Washington, DC: American Psychiatric Association; 1987.


 Lundstrom M, Edlund A, Karlsson S, et al. A multifactorial intervention program reduces the duration of delirium, length of hospitalization, and mortality in delirious patients. J Am Geriatr Soc. 2005;53:622-628.


 Naughton BJ, Saltzman S, Ramadan F, et al. A multifactorial intervention to reduce prevalence of delirium and shorten hospital length of stay. J Am Geriatr Soc. 2005;53:18-23.


 Mittal D, Jimerson NA, Neely EP, et al. Risperidone in the treatment of delirium: results from a prospective open-label trial. J Clin Psychiatry. 2004;65:662-667.


 Sasaki Y, Matsuyama T, Inoue S, et al. A prospective, open-label, flexible-dose study of quetiapine in the treatment of delirium. J Clin Psychiatry. 2003;64:1316-1321.


 Agostini JV, Leo-Summers LS, Inouye SK. Cognitive and other adverse effects of diphenhydramine use in hospitalized older patients. Arch Intern Med. 2001;161:2091-2097.


 Flaherty JH, Morley JE. Delirium: a call to improve current standards of care. J Gerontol A Biol Sci Med Sci. 2004;59:341-343.


 Gagnon B, Low G, Schreier G. Methylphenidate hydrochloride improves cognitive function in patients with advanced cancer and hypoactive delirium: a prospective clinical study. J Psychiatry Neurosci. 2005;30:100-107.