Although current guidelines require physicians to confirm whether a patient’s platelet count is 100,000/µL or higher before administering tissue plasminogen activator (tPA), researchers concluded that this testing might be a poor use of precious time. Bryon P. Jackson, MD, an intern, and colleagues at the University of Pennsylvania Medical Center, Philadephia, conducted a retrospective record review of patients with ischemic stroke. He and coresearchers determined which patients had a platelet count lower than 100,000/µL and whether these patients had a known history of thrombocytopenia or conditions associated with this disorder, such as metastatic cancer, hematologic malignancy, or recent bleeding, or presentation with sepsis or shock.