Managing Schizophrenia Beyond Standard of Care: Insights From Patient Cases
lan Melnick, MD; and Linda Trinh, DNP, discuss how to recognize subtle schizophrenia symptoms through systematic patient engagement, explore the novel mechanism of action and clinical benefits of xanomeline/trospium chloride as a first-in-class muscarinic receptor agonist for treating all three symptom domains of schizophrenia, and share practical strategies for switching patients from traditional antipsychotics while managing side effects and setting appropriate expectations.
EP. 1: Recognizing Schizophrenia Symptoms and Diagnosis
July 28th 2025Panelists discuss how clinicians can better identify subtle and unreported schizophrenia symptoms through systematic evaluation of positive symptoms, negative symptoms, cognitive deficits, and functional impairment, which often requires input from family members and caregivers.
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EP. 2: A Case of a 24-Year-Old Man With Schizophrenia
July 28th 2025Panelists discuss how Jacob’s case demonstrates the importance of recognizing negative symptoms that preceded positive symptoms by nearly a year, and how a partial response to risperidone with continued breakthrough symptoms and cognitive “fogginess” indicates the need for treatment optimization.
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