Major Depressive Disorder

With over 2 dozen FDA-approved antidepressants on the market, it is reasonable to ask: which antidepressants are most effective?

What treatments are effective for mild chronic depression in older patients? Are there novel antidepressant medications with fewer adverse effects than current treatments? In this podcast, experts report on the latest updates in the evaluation and treatment of depression in older adults.

Evidence has accumulated on the efficacy of transcranial direct current stimulation in major depression. The authors review its potential mechanism of action, findings from recent clinical trials, and potential role in the treatment of depressive disorders.

The removal of the so-called “bereavement exclusion” (BE) from DSM-5 was one of the most difficult and controversial decisions the DSM-5 work groups made, and many clinicians continue to find the distinction between ordinary grief and major depression confusing.

What are the psychological and physiological effects of persistent loneliness? How prevalent in the US? What role can cognitive behavioral therapy play for persistently lonely people? In this podcast, an expert offers a brief overview of this underappreciated, but often overlooked, problem.

In this podcast, B. Andrew Farah, MD, looks at shortcomings of current therapy that make treatment-resistant depression so common, offers insights into the genetic underpinnings of TRD, and focuses on a new treatment paradigm.

In this podcast, Dr Eric Plakun give an overview of key points and psychodynamic principles on treatment-resistent mood disorders, based on research and clinical experience.

"Depression is overwhelming and overpowering, and it crushes its prey." Here: a pediatrician tells of her 40-year battle with severe depression, and offers insights about how to talk with someone who is depressed.

For some patients with Parkinson disease, the neuropsychiatric complications are a greater source of morbidity than the motor dysfunction. This article focuses on the management of psychosis in Parkinson disease.

The high rate of recurrence of depressive symptoms and ongoing psychosocial challenges point to the need for a longer-term view of the management of adolescents with depressive disorders.

Vitamin D has been hailed as the “sunshine” vitamin with many therapeutic attributes. The authors explore the association between vitamin D deficiency and increased risk of depression.

Depression is a frequent psychiatric comorbidity among patients with restless leg syndrome. The case presented here illustrates the importance of evaluating for RLS symptoms in patients with major depressive disorder who complain of insomnia.

A reexamination of flurothyl infusions holds promise for improved resolution of severe mood disorders, as well as for a greater understanding of the mechanism of their pathophysiology.

Psychiatrists have found ways to bring their expert skills and knowledge to the care of medically ill patients who are nearing the final phase of life.

Because half of pregnancies in this country are unplanned, it's crucial to counsel women of reproductive potential about their medications-regardless of their plans to conceive.

In order to make positive changes in the field of psychiatry, it is important to appreciate and understand the current challenges and significant limitations of the present approach to psychiatric therapy.

Narcolepsy, cataplexy: symptoms are broad and associated with a range of medical and psychiatric comorbidities. Here: diagnostic and treatment strategies and a look at the BOND study.

The authors focus on the epidemiology of postpartum psychosis, its clinical presentation, etiology, treatment, and strategies to prevent its recurrence.

A look into longer-term clinical and psychosocial outcomes of depressive disorder in early adulthood, as well as clinical and demographic variables associated with recurrence and lack of remission.

Information from studies on adolescents with psychosis and a review of the evidence about the risk of suicide and suicidal behavior in this patient population.

We know so little about community grieving. What is normal and what is not? Perhaps the tragedy in Newtown needs a careful analysis over time.

Demographic shifts and rising life expectancies will lead to an epidemic of chronic neuropsychiatric disease, and societal and public health costs will be enormous. Deep brain stimulation--a procedure that interfaces directly with the neural elements that drive pathological behavior--could be useful.

Mood switching is not uncommon and it is much more prevalent in depressed juveniles than in depressed adults, and there is a large apparent excess of antidepressant-associated switching over reported spontaneous diagnostic changes to bipolar disorder. Details here.

There have been considerable advances in the research on and clinical use of neurostimulation for psychiatric disorders, especially mood disorders and MDD. Three of the most recognized are reviewed here. An experimental new treatment-- trigeminal nerve stimulation-- is also briefly discussed.