Major Depressive Disorder

A 2-year study found a threefold increased risk of cardiovascular disease in older patients with major depression.

With the advent and expansion of social media, we are seeing an increase in the phenomenon of mass humiliation. In this Q&A, we learn what surprised the author of a book on public shaming.

Must clinicians presume that all their female patients of reproductive age are potentially going to become pregnant? And if so, what treatment option should be offered?

When our patients share their misdeeds with us, real or imagined, we can point them to examples of people who have experienced profound shame and managed to put their lives back together.

Which one is Selective Serotonin and which is Reuptake Inhibitor? Some Friday fun.

Like the body’s inevitable arrival at homeostasis, a bereaved person's mind settles-eventually. A peer-to-peer conversation from someone who has been there.

Is it possible to add creative twists to proven therapeutic techniques in order to encourage reluctant patients to try safe and effective treatments that we believe can benefit them? After reading the case, tell us what you think.

The human condition is such that all of us may be vulnerable to seasonal affective disorder. If placed in an environment sufficiently deprived of light we would all develop a reversible syndrome of major depression.

We present the case of a patient for whom different attending providers had markedly different interpretations. As the case unfolds, we invite you to reflect on your diagnostic understanding of each presentation.

Delusional parasitosis can be difficult to recognize, but timely diagnosis and psychiatric treatment can improve quality of life and reduce medical costs.

What therapy is considered the "gold standard” in treating childhood and adolescent depression? Find out in this quiz,

A case report of an acute, transient, reversible depression prompts us to think in a different way about depression.

Metabolic syndrome may be a particularly important marker of antipsychotic metabolic effects.

Some recent breakthroughs, using newly developed neuroscience investigational tools, suggest that if research resources are available, we could soon make substantial advances in understanding the mechanism of action of ECT.

This is usually one of the first questions asked by patients and their families following a psychotic episode, suicide attempt, or manifestation of any serious mental illness. More from the Director of NIMH.

This case of a 14-year-old female patient with end-stage cystic fibrosis illustrates the psychiatrist's critical role in ensuring quality end-of-life care.

Do persons with depression and a history of early life trauma benefit more from psychotherapy or pharmacotherapy? Take the quiz and learn more.

The articles in this Special Report address suicidal behavior in the context of the role of sexual identity, the effects of antidepressants and lithium on suicidal behavior, and clinicians’ reactions in the aftermath of suicide.

As an occupational hazard, preparing for the possibility of patient suicide will help the clinician anticipate the types of support that our colleagues or we may need to weather the event.

Are suicide rates higher or lower during holidays such as Thanksgiving and Christmas? Take the quiz and learn more.

Psychiatrists should be playing a key role in end-of-life decisions as well as, not coincidentally, in pain management.

What percentage of patients hospitalized for depression eventually die by suicide? Learn more in this quiz.

What percentage of depressed patients are resistant to treatment with conventional antidepressant medication?

This article summarizes 5 cases from consultation services at several teaching hospitals. These challenging cases illustrate several points for the consultation/liaison psychiatrist to consider in caring for elderly hospitalized patients.

Clinicians will likely encounter increasing numbers of older adults with late-life depression. Advances in our understanding of the neurobiology can help inform diagnosis and prognosis.