Brian Miller, MD, PhD, MPH

Caffeine use is higher in smokers and in adults with serious mental illness. How does this impact patients with bipolar disorder and schizophrenia?

Researchers performed a nationwide register-based cohort study of patients treated with lithium in Finland.

Sleep and suicide: researchers performed a systematic review and meta-analysis of objective sleep markers of suicidal behaviors in patients with psychiatric disorders.

How do you “see” your patients with ADHD? Researchers performed a systematic review and meta-analysis of ADHD and vision problems.

Researchers analyzed data from the National Survey of Religious Leaders on the state of the psychiatrist-clergy alliance.

There is very modest evidence that clozapine may be associated with improvement of catatonia.

Is inflammation a biomarker of antidepressant efficacy? Researchers analyzed blood CRP levels as a predictor of response to antidepressants.

Genetic testing for severe psychosis? Researchers investigated rare disease-associated copy number variants in patients with treatment-resistant schizophrenia.

Data on the effects of discontinuing lithium on renal function are scarce and conflicting. A new study exploring these effects may aid in the clinical decision-making process.

Metabolic depression? Researchers performed a metabolomic evaluation of patients with treatment-resistant depression.

Smoking and drinking (caffeine): Researchers analyzed caffeine intake and levels in smokers with schizophrenia and bipolar disorder.

Psychiatric Times looks back on the major research on schizophrenia from 2022.

Clozapine for catatonia? Researchers performed a systematic review of the evidence as a treatment for catatonia.

Does research support the efficacy of NAC for negative symptoms in clozapine-resistant patients with schizophrenia?

Does childhood trauma affect outcomes in bipolar disorder? Researchers analyzed the impact of childhood trauma on outcomes in outpatients with bipolar disorder treated with lithium or quetiapine in a randomized clinical trial.

Does route of administration affect antidepressant efficacy of ketamine? Researchers performed a meta-analysis of trials comparing intravenous and intranasal administration.

$chizophrenia: Researchers estimated the economic burden of schizophrenia in the United States.

D for Depression? Researchers performed a 12-week, randomized, double-blind placebo-controlled trial of vitamin D augmentation for major depression with vitamin D deficiency.

Lithium and the kidneys: Researchers analyzed the effects of withdrawal of chronic lithium therapy on renal function.

“Fishing” for novel approaches to depression: Researchers performed randomized dose-finding trial of omega-3 fatty acids for depression with inflammation.

Researchers performed a nationwide cohort study of the use of calcium-channel blockers and adenosine modulators and risk of hospitalization in bipolar disorder.

In a well-blinded study, researchers investigated and directly compared the acute effects of LSD and psilocybin in healthy participants.

A new—cough, cough—combination treatment for depression. Researchers performed an RCT of dextromethorphan-bupropion in major depressive disorder.

Will it hurt my baby? Researchers investigated associations between first trimester exposure to second-generation antipsychotics and major congenital malformations.

What is the optimal dose of aripiprazole as augmentation for treatment-refractory depression? Researchers performed a systematic review and dose-effect meta-analysis.

Researchers performed a systematic review and meta-analysis of the prevalence of bipolar disorder and associated mood episodes in perinatal women.

A recent study demonstrates how large-scale, real-world data analyses can elucidate patterns of disease comorbidity.

This diet was associated with significant reductions in variability of symptoms in patients with bipolar disorder.

Getting the “NAC” of treating negative symptoms: Researchers performed a randomized controlled trial of N-acetylcysteine in clozapine-resistant schizophrenia.

Good night, sleep tight! Researchers performed a 9-year follow-up of sleep disturbance and ADHD symptoms in a population-based cohort study.