Psychopharmacology

Three studies highlight how important it is that when physicians prescribe opioids there can be significant and even potentially fatal consequences for the family members of those for whom they are being prescribed.

Nearly all antibiotic agents have been associated with CNS effects. Although uncommon, these events can be severe.

The good, the bad, and the efficacy of lamotrigine.

Practicing clinical medicine is challenging and stressful enough without the additional burden of being handcuffed by ever-changing medication formularies.

Tinnitus affects 50 million people in the US and can require urgent medical assistance. It can also cause considerable anxiety and even hallucinations. Reducing symptom intensity is key.

Which treatments have proven to be efficacious in meta-analyses as augmentation of clozapine in reducing positive symptoms of schizophrenia? The answer might surprise you.

From drug company mergers to government watchdogs, important trends are emerging.

Most drugs, after journeying through the various metabolic systems throughout the body, find their exit.

Polypharmacy has been met with challenges because many practicing clinical guidelines and treatment algorithms prefer a monotherapy approach.

Lithium’s most serious risk is renal insufficiency, and there are at least 3 ways to protect against this adverse effect. This and other tips to ensure safety.

As a neuropsychiatric and general medical syndrome, catatonia represents an important diagnostic and treatment challenge for all clinicians given its morbidity and mortality.

New research highlights the potential benefits and detriments of treatment strategies for ADHD, including both pharmacological and nonpharmacological options.

Pharmacogenetic testing can provide helpful guidance in the choice of treatment and should be interpreted as a decision-support tool to assist in thoughtful implementation of good clinical care.

These thumbnail sketches of the articles in this Special Report produce an impressionistic sketch of the meaning of the word complicated in psychiatric practice.

An impressive and ever-expanding research literature exists on the topic of pharmacogenomics. Despite this, only four genes have been vetted as clinically actionable.

Finding the right dosage of a psychotropic may be notoriously time consuming, but thought should be granted to the sexually dimorphic expression of CYP450 enzymes when prescribing medication. 

There has been significant improvement in the outcome of many malignancies, which have required balancing anti-tumor immunity and immune toxicity.

Psychiatry has finally crossed into a new paradigm in the treatment of TRD, bringing the glutamate system on board to join the modulation of the monoamine systems.

Traumatic brain injury (TBI) is a public health epidemic. Psychiatric symptoms after TBI are not just common, but also troublesome.

The controversial question of whether to legalize cannabis has emerged front and center as an important issue that deserves a serious and thoughtful dialogue.

Cannabis continues to be the most commonly used illicit drug in the US, and the potential beneficial effects of CBD on cognition in patients with schizophrenia have critical importance.

The profound effects of climate change on mental health have become increasingly difficult to ignore. 

Bupropion is one of the better tolerated antidepressants, but concerns about anxiety, insomnia, and seizures have dampened its popularity. In this podcast, we’ll see how well those concerns hold up to the evidence.

Substance use disorders are a common comorbidity in individuals with bipolar disorder. Adding cariprazine to their medication regimen may improve symptoms of both disorders.