Psychopharmacology

The role of transplant psychiatrists is to assess both transplant and donor candidates to determine capacity to consent to the surgery, recent stressors and coping skills, social supports and availability of caregivers, and whether there are psychological or substance abuse issues that would affect outcomes.

What signs are generally regarded as negative symptoms? What etiological factors contribute to a negative symptom presentation? How to treat these symptoms? Insights here.

The use of buprenorphine for the treatment of opioid dependence is on the rise. However, buprenorphine withdrawal has its own withdrawal symptoms that in many cases can be as severe as symptoms of opioid withdrawal.

When acute, severe adverse effects from a pre-switch antipsychotic occurs, what strategy is recommended? Take the quiz and learn more.

What percentage of depressed patients are resistant to treatment with conventional antidepressant medication?

This article summarizes 5 cases from consultation services at several teaching hospitals. These challenging cases illustrate several points for the consultation/liaison psychiatrist to consider in caring for elderly hospitalized patients.

An in-depth look into the behavioral and psychological symptoms of dementia.

Clinicians will likely encounter increasing numbers of older adults with late-life depression. Advances in our understanding of the neurobiology can help inform diagnosis and prognosis.

Patients with severe depression are more likely to have symptom remission with a combination of cognitive therapy and antidepressant medication than those with less severe or more chronic illness.

The clinician's role is to “translate” symptoms of OCD and understand the dysfunctional circuits at play to decide on the most appropriate treatment for each patient.

In this video, Dr Karl Doghramji, describes the various agents available for managing sleep disorders and discusses the adverse effects associated with over-the-counter, nutraceutical, and prescription sleep aids.

What to do once treatment-resistant depression is established based on risk factors and exclusion of other conditions? Insights here-and a treatment algorithm.

Because cognitive and negative symptoms have the greatest impact on overall recovery, interdisciplinary strategies that target these symptoms are necessary. This article offers details.

The discovery that a single IV infusion of low-dose (subanesthetic) ketamine exerts rapid antidepressant effects constitutes an expansion in our understanding of the neurobiology of depression and provides new avenues for drug development.

To combat opiate abuse and its dire consequences, drug makers have developed a number of strategies--which are detailed here.

Here's a fascinating study of consumer attitudes towards doctors among patients receiving antidepressants. The conclusions help us understand what goes wrong in the doctor-patient relationship and suggest steps needed to fix it.

How can we get even better at customizing treatment for our patients and thereby achieve improved outcomes? How do we avoid becoming relegated to mere brokers of psychopharmacologic commodities? A few thoughts in this brief communication.

A video summarizing key points of a presentation titled “Agitation and Aggression: Managing the Acute Episode and Beyond, An Evidence-Based Approach.”

The menopausal transition is characterized by sex hormone variability and a vulnerability to depressive symptoms and major depressive episodes. The rate of new-onset major depressive episodes is increased during the menopausal transition, as is the experience of depressive symptoms.

The “story behind the story” is not the over-prescription of antidepressants-though it happens-but the under-availability of optimal treatment.

A brief review of interesting new findings on suicidality and depression treatment in youths.

The elephant in the room: the problem of iatrogenic opioid use disorder is being ignored.

Are patients with schizophrenia better off without antipsychotics? Here: a point/counterpoint.

The SSRIs, although principally targeting serotonin transporter, are complex drugs that might work on other neurotransmitter and receptor systems. It is likely worthwhile to look at the effects of other monoamine and neuropeptide systems on the enzymatic machinery cleaving the amyloid precursor protein.

Most, if not all, antidepressants can cause bothersome adverse effects. These are described here along with strategies to help patients cope.

The limited effectiveness of current approaches provide compelling arguments for effective conventional and complementary interventions aimed at preventing PTSD and treating chronic PTSD. Specifics here.

A variety of commonly used psychiatric medications increase the risk of heatstroke, leaving psychiatric patients in jails and prisons at risk.

New national cohort prospective study finds increased, though rare, cardiovascular risks associated with stimulant use in children and adolescents with ADHD. Is your patient at risk?

Very few heavy drinkers receive treatment and fewer still are prescribed medications with demonstrated efficacy. Here, a summary of current research, key takeaways, and highlights from a study on topiramate treatment for heavy drinkers by the lead author of that study.