Psychopharmacology

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Information about the performance of clozapine compared with other treatment strategies in usual practice may impact on its use in routine clinical settings. Here: findings from US national Medicaid data in a cohort of patients with treatment-resistant schizophrenia.

Intended for short-term use, this treatment is associated with specific diagnostic and symptom characteristics, with anhedonia being a stand-out.

Dose escalation is often applied in the management of psychosis when patients do not initially respond to therapy, but a recent study brings this strategy under question.

Is prevention of bipolar disorder possible? What happens before a manic or hypomanic episode that identifies this illness? Researchers asked whether there are any signs or symptoms that predict later diagnosable bipolar disorder with reasonable accuracy.