Major Depressive Disorder

Looking to stay up to date on MDD research? This research collection reviews outcomes on metabolic abnormalities, biomarkers, and more.

Presenters at the 2023 APA Annual Meeting compared definitions of treatment-resistant depression.

Check out this review of the 2023 APA Annual Meeting presentation on the efficacy and safety of repeat treatment courses using novel medicine, zuranolone.

An inside look at what treatments are being discussed in San Francisco...

Study results presented at the 2023 American Psychiatric Association Annual Meeting.

Don't miss this session at the APA 2023 Annual Meeting in San Francisco!

Test your knowledge on issues in major depressive disorder.

First of its kind culturally sensitive adherence scale factors in CVD risk factors to find ways to best support patients.

“Our hope for patients suffering from TRD is that their serious, but often treatable condition is recognized earlier in the treatment paradigm, and they are put on a treatment that works best for their specific type of depression.”

What is the current role of lithium?

From gut microbiota and SSRIs in MDD to nonpharmacological interventions following TBI, here are highlights from the week in Psychiatric Times.

A gut feeling? Researchers analyzed the gut microbiome in major depression disorder and its modulation by SSRI antidepressants.

New results for a study evaluating lumateperone.

Study results show that the therapy activates serotonin (5-HT) and improves stress-coping ability.

The Future of Mental Health: Ketamine Therapy Report revealed that 55% of Americans who tried at home ketamine took more than the recommended dose.

Transcranial direct current stimulation for depression.

Sleep and suicide: researchers performed a systematic review and meta-analysis of objective sleep markers of suicidal behaviors in patients with psychiatric disorders.

Researchers analyzed data from the National Survey of Religious Leaders on the state of the psychiatrist-clergy alliance.

Here are 9 things you need to know about the clinical management of major depressive disorder.

Fatigue is a very common physical complaint. What therapeutic options are available?

Carmen Kosicek, MSN, PMHNP-BC; Charles Montano, MD; and Gus Alva, MD, DFAPA, provide take-home messages for the management of patients with MDD and other depressive disorders.

Experts in psychiatry examine emerging agents and unmet needs for the management of MDD.

"The history of medicine is rich in blaming the disease or the patient for 'untreatable' symptoms, until we stumble upon or develop a treatment that is, in fact, effective."

Charles Montano, MD, and Carmen Kosicek, MSN, PMHNP-BC, comment on the impact of various classes of MDD treatments on time to achieve goals and/or response.