Major Depressive Disorder

Does route of administration affect antidepressant efficacy of ketamine? Researchers performed a meta-analysis of trials comparing intravenous and intranasal administration.

Here’s why most of the claims recently made about antidepressants in Newsweek are wrong.

The first patient in a phase 2/3 study evaluating ulotaront for MDD has been enrolled.

In this CME article, learn how to apply novel treatment approaches for patients with bipolar depression.

Postpartum depression and major depressive disorder in pregnant and postpartum women are severely underdiagnosed and undertreated. How can we more effectively help this patient population?

Is there one state-of-the-art treatment for depression?

In the case of antidepressants, a few recent articles may make it tempting to throw the baby out with the bathwater. But on close examination, that would be a mistake on many levels...

D for Depression? Researchers performed a 12-week, randomized, double-blind placebo-controlled trial of vitamin D augmentation for major depression with vitamin D deficiency.

According to new research, treating depression in older adults could decrease risk of dementia by 51%.

In this CME article, explore the mental health consequences associated with the COVID-19 pandemic as well as the potential role for complementary and alternative approaches.

“Fishing” for novel approaches to depression: Researchers performed randomized dose-finding trial of omega-3 fatty acids for depression with inflammation.

At-home ketamine treatment initiated by an online provider presents many legal, clinical, and ethical challenges...

As patients improve with antidepressant treatment, emotional numbing decreases.

A new—cough, cough—combination treatment for depression. Researchers performed an RCT of dextromethorphan-bupropion in major depressive disorder.

"It would be naïve to believe that targeting a single neurotransmitter, receptor, or circuit in the brain will cure any psychiatric or neurological disorder. However, we would be remiss if we did not try."

What is the optimal dose of aripiprazole as augmentation for treatment-refractory depression? Researchers performed a systematic review and dose-effect meta-analysis.

Dextromethorphan HBr -bupropion HCl extended-release tablets for the treatment of major depressive disorder just became FDA approved.

Is it prolonged grief or MDD? Expert shares insights at premiere annual meeting.

Inaugural recipients will use funds to support infrastructure, student mental health, and programs for children with behavioral challenges.

The SSRIs’ mechanism of action is no index of safety and efficacy.

What are the biggest challenges facing both clinicians and patients, and how can we address them?

A psychiatrist lists the top 8 most pressing issues in MDD, from training to accessibility.

Does a computational approach to the mind pave the way for practicing a biopsychosocial psychiatry?

How can a greater emphasis on valued experiences both promote well-being and alleviate stress in patients?

The American Foundation for Suicide Prevention collaborates with Most Days, a mental health app, to provide suicide prevention expertise and content. Learn more about the partnership here.

Axsome Therapeutics announced the robust antidepressant efficacy demonstrated in this latest study.

Home environments have a clear impact on depression treatment outcomes.

In this CME, review novel, currently available, and promising pharmacological treatment options for treatment-resistant depression.

Zuranolone, a drug for the treatment of major depressive disorder and postpartum disorder, is on a rolling submission of a new drug application.