Major Depressive Disorder

A growing body of scientific evidence suggests that mind-altering drugs, combined with psychotherapy, are effective treatments for some of the most stubborn psychiatric disorders.

Zuranolone showed statistically significant improvement in depressive symptoms in this latest study.

Medical aid in dying is available for psychiatric patients in European countries and Canada. Will the United States be next?

Will a new Canadian law overturn long-held ethical norms in psychiatry?

A daily serving of almonds improved depressive symptoms in diabetes, but will it work in non-diabetic depression?

Overwhelmed and encumbered agencies are increasingly unable to provide critical services for LGBTQ youth, leaving them powerless in impeding a downward spiral into homelessness and associated negative ramifications. There are 5 ways psychiatrists can help.

What treatments could handle both psychiatric emergencies and long-standings mental health conditions—in a hurry?

Can depression be passed on to future generations, and if it can, how can treatment help?

Sedation may not always be desirable, but it is difficult to avoid in psychiatry. Some of the most sedating medications are discussed.

The psychiatrist's armamentarium to treat depression holds promise with a growing arsenal of integrative and pharmacologic options.

The FDA cleared the way to use this deep transcranial magnetic stimulation system, which may be able to help treat depression in less than 5 minutes.

A recent study evaluated the everyday efficacy of this novel treatment for major depressive disorder.

Pain as a cultural construct considers conscious and unconscious biases, as well as methods for assessing and managing pain in all patient populations, including those with mental health challenges.

A study estimates the frequency and clinical correlates of GI symptoms during depressive episodes in a large, nationwide sample of patients with MDD in China.

A quick primer on nomenclature, issues to consider, and switching.

ECT has undoubtedly been foundational in the field of interventional psychiatry, yet controversy remains an underlying theme.

There is consistent evidence of benefits following state-of-the-art modified ECT.

No one has precise data about how many Americans receive ECT each year, let alone how many treatments each patients receives or how closely providers space treatments. This is a troubling dilemma, according to the authors.

The more tools we have in our treatment toolbox, the greater the likelihood that we will ultimately find a treatment (or combination of treatments) to improve a given patient’s functioning and quality of life.

General medical illness can contribute to affective disorders in elderly patients. Treating the medical illness is an integral part in treating depression in these patients.

In approximately half of patients with Huntington disease, symptoms of depression, irritability/aggression, executive dysfunction, psychosis, cognitive decline, and dementia present long before progressive motor symptoms.

A myriad of neuropsychiatric symptoms result from folate deficiency, including cognitive impairment, insomnia, psychosis, depression, peripheral sensory deficits, and weakness. Treatment and prevention strategies are discussed.

New data from the ongoing SHORELINE study may bring good news for treating MDD.

Patients with cancer are at increased risk for both suicidal ideation and completed suicide. The authors discuss factors contributing to this increase in both biological and psychological realms.

The story of depression, through time and around the world.

How do defective neuro-glia interactions contribute to depression?

How does relapse prevention for depression in patients with coronary heart disease differ from relapse prevention in those with depression alone? That question and more answered.

Although supported by basic science, it’s still a sea change to think that diet can treat depression. Some research puts that idea to the test.

Two recent papers look at the subtle and surprising links between smoking and pain in different parts of the body.

Despite alcohol-related fatalities soaring to the No. 1 cause of death in middle-aged adults, this medication is often overlooked.