Major Depressive Disorder

This 2-part Special Report devotes itself to the new inflammatory world that clinicians and researchers find themselves in. Most of our prior and current preconceptions about the role of immunity and mental illness have been-and are-wrong.

Relapse in MDD is associated with morphologic brain changes; stopping exercise may increase depressive symptoms; and inflammatory biomarkers may predict which treatment-resistant MDD patients benefit from ECT.

Pretreatment assessment of functional brain connectivity in patients with major depressive disorder may predict treatment response, according to new study.

Empirically supported psychotherapeutic treatments have been shown to reduce symptoms of depression and build problem-solving skills in adolescents. Three of those treatments are discussed in this 10-question quiz.

Make the most of brief psychotherapeutic sessions with these practical tips.

In the elderly, falls are a common and important problem. In the US, fall-related injuries cost approximately $30 billion per year, and about 30% of older adults fall at least once in a given year.

Are we happier when we don’t eat sugar or gluten and should we all be gluten-free?

Functional connectivity is a “rapidly developing scientific story.” And for psychiatrists, it is a story worth following.

Three new studies on genetic risk factors and lifestyle; the transition from cognitive health to Alzheimer disease; and metabolic syndrome in depressed older adults.

What are the major cortical networks we are trying to change with TMS? Where will TMS fit into psychiatry in the next decade? These questions and more are addressed in this podcast.

An expert Q&A about the experience of TMS treatment and the future of neuromodulation as it transitions from research to practice.

Recent studies have demonstrated the wide-reaching adverse effects of being bullied in childhood. These effects range from impaired academic performance to interest in cosmetic surgery.

It’s an FDA approved technology, but what exactly is TMS and why should you be aware of it?

“We were surprised to find that SSRIs and other antidepressants aren’t very effective at keeping depressed patients out of hospital.”

Among the topics covered in this year's noteworthy studies: lithium and suicide prevention, mixed depression, and light therapy.

Questions and caveats about dosing remain.

What is the estimated prevalence of psychiatric disorders in ambulatory patients with cancer? Find out in this quiz.

Researchers investigate links between depression and exercise, childhood sexual abuse, and diet.

Recommendations from an international panel of experts on the management of MDD.

The latest news in the treatment of depression covers patient self-management apps, antidepressant efficacy in older adults, and strategies to improve adherence.

Here: an alternative to the trial-and-error method that can boost treatment response rates.

Is an effective, well-tolerated treatment for the negative symptoms of schizophrenia on the horizon?

Grief vs depression? MDD vs depressive episodes? SGAs in treatment-resistant depression? Treatment-emergent sexual dysfunction? Insights in this Q&A.

When is the most favorable time for light therapy for seasonal affective disorder? Take the quiz to learn more.

What factors predispose patients to TRD and what treatment strategies achieve response? Find out here, with a bonus case vignette.