Alzheimer Disease & Dementia

What is the most common problem in individuals with dementia?

Although delusional jealousy was described as an initial symptom in Alois Alzheimer’s first case report, little is known about its clinical features and prognosis in dementia.

This film is a must-see for psychiatrists, not because it adds new information about the course of Alzheimer disease or its impact on families, but because it forces us to rethink issues that can affect our clinical practice.

Therapeutic lying, a concept that is currently seeping into the medical literature, is the practice of deliberately deceiving patients for reasons considered in their best interest.

What role might electroconvulsive therapy play for short-term treatment of agitation and aggression in patients with dementia?

The potential of TMS as a treatment for cognitive disorders, fatigue, pain, and other manifestations of brain disease is discussed, as is the encouraging prospect for neuropsychiatric management of many patients.

An in-depth look into the behavioral and psychological symptoms of dementia.

This case stresses the importance of identifying cultural issues that arise in mental health clinical encounters.

The SSRIs, although principally targeting serotonin transporter, are complex drugs that might work on other neurotransmitter and receptor systems. It is likely worthwhile to look at the effects of other monoamine and neuropeptide systems on the enzymatic machinery cleaving the amyloid precursor protein.

Vascular surgeons, internists, and neurologists all exist-but why aren’t there any vascular psychiatrists? There certainly is a need.

In the trenches of Alzheimer research, the battle continues . . . but where do we stand? Is the war on AD dementia nearing conclusion, or are we simply in the initial throes of the fight? Three experts weigh in.

Placing black floor mats in front of exits to deter demented nursing home residents from dangerous wandering may pose ethical questions.

Alzheimer disease psychosis appears to be a distinct clinical entity. This article focuses on management strategies.

Demographic shifts and rising life expectancies will lead to an epidemic of chronic neuropsychiatric disease, and societal and public health costs will be enormous. Deep brain stimulation--a procedure that interfaces directly with the neural elements that drive pathological behavior--could be useful.

Big things are happening in Alzheimer disease research. Recent developments are shaping the future for assessment and diagnosis and allowing for early detection and treatment of the disease.

While the growing evidence base for the positive effects of lithium on brain health is compelling, the evidence remains preliminary.

We have the target protein for Alzheimer, the antibody to knock out the protein, and the imaging test locating the protein in the brain, but there still remains one problem . . . who should receive the antibody?

Results of a 10-week prospective study, recently reported at the Annual Meeting of the American Association for Geriatric Psychiatry, offered no conclusive evidence about the mortality risk of elderly patients with Alzheimer disease who were treated with antipsychotics.

Despite the prevalent perception that cognitive decline in the aged population is inevitable, researchers with Northwestern University's SuperAging Project are finding that "excellent memory capacity in late life is a biological possibility."

Because of new imaging techniques and advances in our understanding of neurophysiology, neurological and psychiatric disorders are increasingly being recognized as disorders of circuit functions in the brain. Using techniques such as DBS, neurosurgeons are able to pinpoint malfunctioning circuits and to recalibrate them.

Which of the following complementary and alternative medicine (CAM) therapies may have beneficial effects on symptoms of mild cognitive impairment (MCI) and Alzheimer disease (AD)?

Mental illness is a risk factor for HIV infection. It brings a number of behavioral correlates that put patients at risk for getting infected. As HIV infection worsens, it begins to affect the brain, and cyclical relationship between the disease and mental illness begins.

Less common but still important syndromes connected with Alzheimer disease include traumatic brain injury, infectious and inflammatory disorders, alcohol-induced dementia.

Psychiatric disorders, such as primary sleep disturbances, depression, substance abuse, mania, sexually inappropriate behaviors, and psychosis, can complicate the care of patients with dementia.

The goal of this article is to improve recognition of comorbid psychiatric and movement disorders and to help the reader formulate a management strategy using a multidisciplinary approach.