The SSRIs, although principally targeting serotonin transporter, are complex drugs that might work on other neurotransmitter and receptor systems. It is likely worthwhile to look at the effects of other monoamine and neuropeptide systems on the enzymatic machinery cleaving the amyloid precursor protein.
Vascular surgeons, internists, and neurologists all exist-but why aren’t there any vascular psychiatrists? There certainly is a need.
In the trenches of Alzheimer research, the battle continues . . . but where do we stand? Is the war on AD dementia nearing conclusion, or are we simply in the initial throes of the fight? Three experts weigh in.
Placing black floor mats in front of exits to deter demented nursing home residents from dangerous wandering may pose ethical questions.
Alzheimer disease psychosis appears to be a distinct clinical entity. This article focuses on management strategies.
Demographic shifts and rising life expectancies will lead to an epidemic of chronic neuropsychiatric disease, and societal and public health costs will be enormous. Deep brain stimulation--a procedure that interfaces directly with the neural elements that drive pathological behavior--could be useful.
Big things are happening in Alzheimer disease research. Recent developments are shaping the future for assessment and diagnosis and allowing for early detection and treatment of the disease.
While the growing evidence base for the positive effects of lithium on brain health is compelling, the evidence remains preliminary.
We have the target protein for Alzheimer, the antibody to knock out the protein, and the imaging test locating the protein in the brain, but there still remains one problem . . . who should receive the antibody?
Results of a 10-week prospective study, recently reported at the Annual Meeting of the American Association for Geriatric Psychiatry, offered no conclusive evidence about the mortality risk of elderly patients with Alzheimer disease who were treated with antipsychotics.
Despite the prevalent perception that cognitive decline in the aged population is inevitable, researchers with Northwestern University's SuperAging Project are finding that "excellent memory capacity in late life is a biological possibility."
Because of new imaging techniques and advances in our understanding of neurophysiology, neurological and psychiatric disorders are increasingly being recognized as disorders of circuit functions in the brain. Using techniques such as DBS, neurosurgeons are able to pinpoint malfunctioning circuits and to recalibrate them.
Which of the following complementary and alternative medicine (CAM) therapies may have beneficial effects on symptoms of mild cognitive impairment (MCI) and Alzheimer disease (AD)?
Mental illness is a risk factor for HIV infection. It brings a number of behavioral correlates that put patients at risk for getting infected. As HIV infection worsens, it begins to affect the brain, and cyclical relationship between the disease and mental illness begins.
Less common but still important syndromes connected with Alzheimer disease include traumatic brain injury, infectious and inflammatory disorders, alcohol-induced dementia.
Psychiatric disorders, such as primary sleep disturbances, depression, substance abuse, mania, sexually inappropriate behaviors, and psychosis, can complicate the care of patients with dementia.
The goal of this article is to improve recognition of comorbid psychiatric and movement disorders and to help the reader formulate a management strategy using a multidisciplinary approach.
The evolution of deep brain stimulation for various neuropsychiatric disorders results from advances in structural and functional brain imaging, increased understanding of neurocircuitry of the brain, and improvements in neurosurgical techniques and equipment.
The number of medical diseases that can present with psychotic symptoms (ie, delusions, hallucinations) is legion. A thorough differential diagnosis of possible medical and toxic causes of psychosis is necessary to avoid the mistaken attribution of psychosis to a psychiatric disorder.
When this physician published an article containing his case summaries of 3 women with dementia praecox, he made it clear that this was a disease that neurologists and physicians in general practice could easily and reliably diagnose by following his diagnostic procedures.
The proposed new diagnostic categories and guidelines for Alzheimer's disease include not only dementia, but also the preclinical and mild cognitive impairment (MCI) phases of AD.
Of the 3 informative articles included in this special geriatric collection, 1 offers a perspective on the treatment of depression that does not focus on somatotherapy. The others remind us of 2 additional geriatric Ds of importance: drugs and driving.
Medical professionals may be reluctant to initiate a discussion about driving with older patients in anticipation of a negative impact on the physician-patient relationship.
New diagnostic guidelines and advanced screening tools enable clinicians to detect dementia and Alzheimer disease earlier than ever.
Age is a major risk factor for the development of Alzheimer disease and other dementias. New technologies in brain imaging represent major advances in our ability to diagnose age-related cognitive and behavioral disorders.
